@article{oai:u-ryukyu.repo.nii.ac.jp:02011138,
 author = {Naka, Izumi and Ohashi, Jun and Kimura, Ryosuke and Inaoka, Tsukasa and Matsumura, Yasuhiro},
 journal = {Lipids in Health and Disease},
 month = {Jul},
 note = {Background:Our previous study demonstrated that the A-allele of the single nucleotide polymorphism (SNP) rs34623097 located in the upstream region of the β2 adrenergic receptor gene (ADRB2) is significantly associated with risk for obesity in Oceanic populations.\nMethods:To investigate whether the ADRB2 polymorphisms explain part of the individual differences in lipid mobilization, energy expenditure and glycogen breakdown, the associations of 10 ADRB2 SNPs with total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride levels were examined in 128 adults in Tonga.\nResults:A multiple linear regression analysis adjusted for age, sex, and body mass index revealed that rs34623097 was significantly associated with triglyceride levels (P-value = 0.037). A copy of the rs34623097-A allele increased serum triglyceride levels by 70.1 mg/dL (0.791 mmol/L). None of the ADRB2 SNPs showed a significant association with total-cholesterol, high-density lipoprotein cholesterol, or low-density lipoprotein cholesterol.\nConclusions:In a Tongan population, a SNP located in the upstream region of ADRB2 is associated with triglyceride levels independent of body mass index., 論文},
 title = {Association of ADRB2 polymorphism with triglyceride levels in Tongans},
 volume = {12},
 year = {2013}
}