{"created":"2022-02-01T06:35:36.606871+00:00","id":2011138,"links":{},"metadata":{"_buckets":{"deposit":"36a4cc1b-4b66-435e-b1ea-81a5281d7cca"},"_deposit":{"id":"2011138","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2011138"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02011138","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Association of ADRB2 polymorphism with triglyceride levels in Tongans","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Naka, Izumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohashi, Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kimura, Ryosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Inaoka, Tsukasa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsumura, Yasuhiro","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"en","subitem_1522651041219":"Creative Commons Attribution 2.0 right"},{"subitem_1522650717957":"en","subitem_1522650727486":"https://creativecommons.org/licenses/by/2.0/","subitem_1522651041219":"https://creativecommons.org/licenses/by/2.0/"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"β2 adrenergic receptor gene"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Body mass index"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Polymorphism"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Triglycerides"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Background:Our previous study demonstrated that the A-allele of the single nucleotide polymorphism (SNP) rs34623097 located in the upstream region of the β2 adrenergic receptor gene (ADRB2) is significantly associated with risk for obesity in Oceanic populations.\\nMethods:To investigate whether the ADRB2 polymorphisms explain part of the individual differences in lipid mobilization, energy expenditure and glycogen breakdown, the associations of 10 ADRB2 SNPs with total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride levels were examined in 128 adults in Tonga.\\nResults:A multiple linear regression analysis adjusted for age, sex, and body mass index revealed that rs34623097 was significantly associated with triglyceride levels (P-value = 0.037). A copy of the rs34623097-A allele increased serum triglyceride levels by 70.1 mg/dL (0.791 mmol/L). None of the ADRB2 SNPs showed a significant association with total-cholesterol, high-density lipoprotein cholesterol, or low-density lipoprotein cholesterol.\\nConclusions:In a Tongan population, a SNP located in the upstream region of ADRB2 is associated with triglyceride levels independent of body mass index.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"BioMed Central"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/46973"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1476-511X"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"Lipids in Health and Disease"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-07-23","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"12"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1186/1476-511X-12-110"}},{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1186/1476-511X-12-110"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"Naka2013_Article_AssociationOfADRB2Polymorphism.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2011138/files/Naka2013_Article_AssociationOfADRB2Polymorphism.pdf"},"version_id":"e16965f6-b63a-44dd-9c52-e69937a16ddd"}]},"item_title":"Association of ADRB2 polymorphism with triglyceride levels in Tongans","item_type_id":"15","owner":"1","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-13"},"publish_date":"2020-10-13","publish_status":"0","recid":"2011138","relation_version_is_last":true,"title":["Association of ADRB2 polymorphism with triglyceride levels in Tongans"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-03T05:36:01.250004+00:00"}