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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

The fine-scale genetic structure and evolution of the Japanese population

http://hdl.handle.net/20.500.12000/47029
http://hdl.handle.net/20.500.12000/47029
24fe6749-eef7-4e6a-81cd-950b92e736e4
名前 / ファイル ライセンス アクション
journal.pone.0185487.pdf journal.pone.0185487.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-10-20
タイトル
タイトル The fine-scale genetic structure and evolution of the Japanese population
言語 en
作成者 Takeuchi, Fumihiko

× Takeuchi, Fumihiko

en Takeuchi, Fumihiko

Katsuya, Tomohiro

× Katsuya, Tomohiro

en Katsuya, Tomohiro

Kimura, Ryosuke

× Kimura, Ryosuke

en Kimura, Ryosuke

Nabika, Toru

× Nabika, Toru

en Nabika, Toru

Isomura, Minoru

× Isomura, Minoru

en Isomura, Minoru

Ohkubo, Takayoshi

× Ohkubo, Takayoshi

en Ohkubo, Takayoshi

Tabara, Yasuharu

× Tabara, Yasuharu

en Tabara, Yasuharu

Yamamoto, Ken

× Yamamoto, Ken

en Yamamoto, Ken

Yokota, Mitsuhiro

× Yokota, Mitsuhiro

en Yokota, Mitsuhiro

Liu, Xuanyao

× Liu, Xuanyao

en Liu, Xuanyao

Saw, Woei-Yuh

× Saw, Woei-Yuh

en Saw, Woei-Yuh

Mamatyusupu, Dolikun

× Mamatyusupu, Dolikun

en Mamatyusupu, Dolikun

Yang, Wenjun

× Yang, Wenjun

en Yang, Wenjun

Xu, Shuhua

× Xu, Shuhua

en Xu, Shuhua

Teo, Yik-Ying

× Teo, Yik-Ying

en Teo, Yik-Ying

Kato, Norihiro

× Kato, Norihiro

en Kato, Norihiro

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution 4.0 right
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 https://creativecommons.org/licenses/by/4.0/
内容記述
内容記述タイプ Other
内容記述 The contemporary Japanese populations largely consist of three genetically distinct groups—Hondo, Ryukyu and Ainu. By principal-component analysis, while the three groups can be clearly separated, the Hondo people, comprising 99% of the Japanese, form one almost indistinguishable cluster. To understand fine-scale genetic structure, we applied powerful haplotype-based statistical methods to genome-wide single nucleotide polymorphism data from 1600 Japanese individuals, sampled from eight distinct regions in Japan. We then combined the Japanese data with 26 other Asian populations data to analyze the shared ancestry and genetic differentiation. We found that the Japanese could be separated into nine genetic clusters in our dataset, showing a marked concordance with geography; and that major components of ancestry profile of Japanese were from the Korean and Han Chinese clusters. We also detected and dated admixture in the Japanese. While genetic differentiation between Ryukyu and Hondo was suggested to be caused in part by positive selection, genetic differentiation among the Hondo clusters appeared to result principally from genetic drift. Notably, in Asians, we found the possibility that positive selection accentuated genetic differentiation among distant populations but attenuated genetic differentiation among close populations. These findings are significant for studies of human evolution and medical genetics.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Public Library of Science
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47029
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0185487
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0185487
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1932-6203
収録物名
言語 en
収録物名 PLoS ONE
書誌情報
巻 12, 号 11
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