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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Conservation of a Neutralization Epitope of Human T-cell Leukemia Virus Type 1 (HTLV-1) among Currently Endemic Clinical Isolates in Okinawa, Japan

http://hdl.handle.net/20.500.12000/47225
http://hdl.handle.net/20.500.12000/47225
46a2f41f-9829-42a1-a2be-ebfd01a8beaf
名前 / ファイル ライセンス アクション
pathogens-09-00082-v2.pdf pathogens-09-00082-v2.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-11-16
タイトル
タイトル Conservation of a Neutralization Epitope of Human T-cell Leukemia Virus Type 1 (HTLV-1) among Currently Endemic Clinical Isolates in Okinawa, Japan
言語 en
作成者 Mizuguchi, Mariko

× Mizuguchi, Mariko

en Mizuguchi, Mariko

Takahashi, Yoshiaki

× Takahashi, Yoshiaki

en Takahashi, Yoshiaki

Tanaka, Reiko

× Tanaka, Reiko

en Tanaka, Reiko

Fukushima, Takuya

× Fukushima, Takuya

en Fukushima, Takuya

Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution 4.0 right
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 https://creativecommons.org/licenses/by/4.0/
主題
言語 en
主題Scheme Other
主題 human T-cell leukemia virus type 1 (HTLV-1)
言語 en
主題Scheme Other
主題 adult T-cell leukemia/lymphoma (ATL)
言語 en
主題Scheme Other
主題 HTLV-1 envelope gp46
言語 en
主題Scheme Other
主題 neutralization epitope
内容記述
内容記述タイプ Other
内容記述 Approximately one-tenth of the 10 million individuals living with human T-cell leukemia virus type-1 (HTLV-1) worldwide live in Japan. Most of these infected individuals live in the southwest region of Japan, including Okinawa prefecture; however, currently no prophylactic vaccine against HTLV-1 infection is available. For preventing the HTLV-1 spread, we previously generated a humanized monoclonal antibody (hu-LAT-27) that mediates both neutralization and antibody-dependent cellular cytotoxicity (ADCC). The neutralization epitope of LAT-27 is a linear amino acid sequence from residue 191 to 196 (Leu-Pro-His-Ser-Asn-Leu) of the HTLV-1 envelope gp46 protein. Here, we found that the LAT-27 epitope is well conserved among HTLV-1 clinical isolates prevalent in Okinawa. The hu-LAT-27 treatment inhibited syncytium formation by these clinical HTLV-1 isolates. Although an amino acid substitution at residue 192 in the LAT-27 epitope from proline to serine was found in a few HTLV-1 isolates, hu-LAT-27 could still react with a synthetic peptide carrying this amino acid substitution. These findings demonstrate the wide spectrum of hu-LAT-27 reactivity, suggesting that hu-LAT-27 may be a candidate drug for prophylactic passive immunization against HTLV-1 infection.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 MDPI
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47225
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3390/pathogens9020082
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3390/pathogens9020082
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2076-0817
収録物名
言語 en
収録物名 Pathogens
書誌情報
巻 9, 号 2, 発行日 2020-01-27
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