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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T‐cell leukemia/lymphoma

http://hdl.handle.net/20.500.12000/47231
http://hdl.handle.net/20.500.12000/47231
4f7d5ab6-3200-457b-89ab-cf59f51a0071
名前 / ファイル ライセンス アクション
cas.14114.pdf cas.14114.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-11-16
タイトル
タイトル Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T‐cell leukemia/lymphoma
言語 ja
作成者 Morichika, Kazuho

× Morichika, Kazuho

en Morichika, Kazuho

Karube, Kennosuke

× Karube, Kennosuke

en Karube, Kennosuke

Kayo, Hirona

× Kayo, Hirona

en Kayo, Hirona

Uchino, Shuta

× Uchino, Shuta

en Uchino, Shuta

Nishi, Yukiko

× Nishi, Yukiko

en Nishi, Yukiko

Nakachi, Sawako

× Nakachi, Sawako

en Nakachi, Sawako

Okamoto, Shiki

× Okamoto, Shiki

en Okamoto, Shiki

Morishima, Satoko

× Morishima, Satoko

en Morishima, Satoko

Ohshiro, Kazuiku

× Ohshiro, Kazuiku

en Ohshiro, Kazuiku

Nakazato, Iwao

× Nakazato, Iwao

en Nakazato, Iwao

Fukushima, Takuya

× Fukushima, Takuya

en Fukushima, Takuya

Masuzaki, Hiroaki

× Masuzaki, Hiroaki

en Masuzaki, Hiroaki

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution-NonCommercial 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc/4.0/
権利情報 https://creativecommons.org/licenses/by-nc/4.0/
主題
言語 ja
主題Scheme Other
主題 adult T‐cell leukemia/lymphoma
内容記述
内容記述タイプ Other
内容記述 Adult T‐cell leukemia/lymphoma (ATLL) is a mature T‐cell neoplasm, and is divided into 2 indolent (smoldering and chronic) and 2 aggressive (acute and lymphoma) clinical subtypes. Based on previous integrated molecular analyses suggesting the importance of the JAK‐STAT pathway in ATLL, we attempted to clarify the clinicopathological significance of this pathway. Clinical and morphological findings were reviewed in 116 cases with ATLL. The nuclear localizations of phosphorylated STAT3 (pSTAT3), pSTAT5, and pSTAT6 were analyzed by immunohistochemistry. Targeted sequencing was undertaken on the portion of STAT3 encoding the Src homology 2 domain. Expression of pSTAT3 was observed in 43% (50/116) of ATLL cases, whereas pSTAT5 and pSTAT6 were largely undetected. Cases with the lymphoma type showed significantly less frequent pSTAT3 expression (8/45, 18%) than those with the other subtypes (41/66, 62%; P < .001). STAT3 mutations were detected in 36% (10/28) and 19% (12/64) of cases with the smoldering and aggressive types of ATLL, respectively. The correlation between STAT3 mutation and pSTAT3 expression was not significant (P = .07). Both univariate and multivariate analysis revealed that pSTAT3 expression was significantly associated with better overall survival and progression‐free survival in the smoldering type of ATLL, whereas STAT3 mutation was not related to a line of clinical outcome. Collectively, our data show that only the lymphoma type showed a low prevalence of tumor cells positive for pSTAT3 expression, and raises the possibility that pSTAT3 expression is a novel biomarker to predict better prognosis in the smoldering type of ATLL.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47231
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/cas.14114
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/cas.14114
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1349-7006
収録物識別子タイプ ISSN
収録物識別子 1347-9032
収録物名
言語 en
収録物名 Cancer Science
書誌情報
巻 110, 号 9, p. 2982-2991, 発行日 2019-09
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