{"created":"2022-02-01T06:41:09.035831+00:00","id":2011302,"links":{},"metadata":{"_buckets":{"deposit":"af08525a-7c1e-409f-a9bc-24171c287d77"},"_deposit":{"id":"2011302","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2011302"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02011302","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsuchida, Akio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Senda, Motohiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ito, Akihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Saito, Seiichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kiso, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ando, Takayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Harduin-Lepers, Anne","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsuda, Akio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Furukawa, Keiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Furukawa, Koichi","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"en","subitem_1522651041219":"Creative Commons Attribution 4.0"},{"subitem_1522650717957":"en","subitem_1522650727486":"https://creativecommons.org/licenses/by/4.0/","subitem_1522651041219":"https://creativecommons.org/licenses/by/4.0/"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"GalNAc-disialyl Lc4 (GalNAc-DSLc4) was reported as a novel antigen that associated with malignant features of renal cell cancers (RCCs). To clarify roles of GalNAc-DSLc4 in malignant properties of RCCs, we identified B4GalNAc-T2 as a responsible gene for the synthesis of GalNAc-DSLc4, and prepared stable transfectants of GalNAc-T2 cDNA using VMRC-RCW cells, resulting in the establishment of high expressants of GalNAc-DSLc4. They showed increased proliferation and invasion, and specific adhesion to laminin. In the transfectants, PI3K/Akt signals were highly activated by serum stimulation or adhesion to laminin. GalNAc-DSLc4 was co-localized in lipid rafts with integrin β1 and caveolin-1 in both immunoblotting of fractionated detergent extracts and immunocytostaining, particularly when stimulated with serum. Masking of GalNAc-DSLc4 with antibodies as well as PI3K inhibitor suppressed malignant properties of the transfectants. These results suggested that GalNAc-DSLc4 is involved in malignant properties of RCCs by forming a molecular complex with integrins in lipid rafts.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"Springer Nature"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/47490"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"2045-2322"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"Scientific Reports"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-04","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"8"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1038/s41598-018-25521-6"}},{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1038/s41598-018-25521-6"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"s41598-018-25521-6.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2011302/files/s41598-018-25521-6.pdf"},"version_id":"528510f0-c7d2-49d6-92a7-e46acd8283c2"}]},"item_title":"Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells","item_type_id":"15","owner":"1","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-15"},"publish_date":"2020-12-15","publish_status":"0","recid":"2011302","relation_version_is_last":true,"title":["Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-03T05:31:06.279480+00:00"}