{"_buckets": {"deposit": "98541370-24a7-4cb6-8268-aab851d1dacd"}, "_deposit": {"id": "2011308", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2011308"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02011308", "sets": ["1642838338003", "1642838407795"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakamura, Yuichiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Miyata, Yasuyoshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Matsuo, Tomohiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Shida, Yohei", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hakariya, Tomoaki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohba, Kojiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Taima, Takenobu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ito, Akihiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Suda, Tetsuji", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hakomori, Sen-itiroh", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Saito, Seiichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sakai, Hideki", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "en", "subitem_1522651041219": "Creative Commons Attribution 4.0"}, {"subitem_1522650717957": "en", "subitem_1522650727486": "https://creativecommons.org/licenses/by/4.0/", "subitem_1522651041219": "https://creativecommons.org/licenses/by/4.0/"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "SSEA-4"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "Tumor-infiltrating immune cells"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "Biochemical recurrence"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "Apoptosis · prostate cancer"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Stage-specific embryonic antigen-4 (SSEA-4), a specific marker for pluripotent stem cells, plays an important role in the malignant behavior of several cancers. Here, SSEA-4 expression was evaluated by immunohistochemistry using monoclonal antibody RM1 specific to SSEA-4 in 181 and 117 prostate cancer (PC) specimens obtained by biopsy and radical prostatectomy (RP), respectively. The relationships between SSEA-4 expression in cancer cells or the presence of SSEA-4-positive tumor-infiltrating immune cells (TICs) and clinicopathological parameters were analyzed. SSEA-4 expression in cancer cells was significantly associated with Gleason score, local progression, and lymph node and distant metastasis. In RP specimens, high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs were significant predictors of pT3, i.e., invasion and worse biochemical recurrence (BCR) after RP, respectively, in univariate analysis. In contrast, combination of high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs was an independent predictor for pT3 and BCR in multivariate analysis. Biologically this combination was also independently associated with suppression of apoptosis. Thus, the co-expression of SSEA-4 in cancer cells and TICs may have crucial roles in the malignant aggressiveness and prognosis of PC. Invasive potential and suppression of apoptosis may be linked to SSEA-4 expression.", "subitem_description_type": "Other"}, {"subitem_description": "論文", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "en", "subitem_1522300316516": "Springer Nature"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/47508"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1573-4986"}, {"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0282-0080"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "Glycoconjugate Journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-06-26", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "418", "bibliographicPageStart": "409", "bibliographicVolumeNumber": "36"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1007/s10719-019-09882-2"}}, {"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1007/s10719-019-09882-2"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "Nakamura2019_Article_Stage-specificEmbryonicAntigen.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2011308/files/Nakamura2019_Article_Stage-specificEmbryonicAntigen.pdf"}, "version_id": "461beee2-3092-4009-85e9-9d3b88682086"}]}, "item_title": "Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer", "item_type_id": "15", "owner": "1", "path": ["1642838338003", "1642838407795"], "permalink_uri": "http://hdl.handle.net/20.500.12000/47508", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-12-16"}, "publish_date": "2020-12-16", "publish_status": "0", "recid": "2011308", "relation": {}, "relation_version_is_last": true, "title": ["Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer"], "weko_shared_id": -1}