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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer

http://hdl.handle.net/20.500.12000/47508
http://hdl.handle.net/20.500.12000/47508
133131b6-8f2f-4283-97f1-1ecc7b50ae3b
名前 / ファイル ライセンス アクション
Nakamura2019_Article_Stage-specificEmbryonicAntigen.pdf Nakamura2019_Article_Stage-specificEmbryonicAntigen.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-12-16
タイトル
タイトル Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer
言語 en
作成者 Nakamura, Yuichiro

× Nakamura, Yuichiro

en Nakamura, Yuichiro

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Miyata, Yasuyoshi

× Miyata, Yasuyoshi

en Miyata, Yasuyoshi

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Matsuo, Tomohiro

× Matsuo, Tomohiro

en Matsuo, Tomohiro

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Shida, Yohei

× Shida, Yohei

en Shida, Yohei

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Hakariya, Tomoaki

× Hakariya, Tomoaki

en Hakariya, Tomoaki

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Ohba, Kojiro

× Ohba, Kojiro

en Ohba, Kojiro

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Taima, Takenobu

× Taima, Takenobu

en Taima, Takenobu

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Ito, Akihiro

× Ito, Akihiro

en Ito, Akihiro

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Suda, Tetsuji

× Suda, Tetsuji

en Suda, Tetsuji

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Hakomori, Sen-itiroh

× Hakomori, Sen-itiroh

en Hakomori, Sen-itiroh

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Saito, Seiichi

× Saito, Seiichi

en Saito, Seiichi

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Sakai, Hideki

× Sakai, Hideki

en Sakai, Hideki

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution 4.0
権利情報
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 https://creativecommons.org/licenses/by/4.0/
主題
言語 en
主題Scheme Other
主題 SSEA-4
主題
言語 en
主題Scheme Other
主題 Tumor-infiltrating immune cells
主題
言語 en
主題Scheme Other
主題 Biochemical recurrence
主題
言語 ja
主題Scheme Other
主題 Apoptosis · prostate cancer
内容記述
内容記述タイプ Other
内容記述 Stage-specific embryonic antigen-4 (SSEA-4), a specific marker for pluripotent stem cells, plays an important role in the malignant behavior of several cancers. Here, SSEA-4 expression was evaluated by immunohistochemistry using monoclonal antibody RM1 specific to SSEA-4 in 181 and 117 prostate cancer (PC) specimens obtained by biopsy and radical prostatectomy (RP), respectively. The relationships between SSEA-4 expression in cancer cells or the presence of SSEA-4-positive tumor-infiltrating immune cells (TICs) and clinicopathological parameters were analyzed. SSEA-4 expression in cancer cells was significantly associated with Gleason score, local progression, and lymph node and distant metastasis. In RP specimens, high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs were significant predictors of pT3, i.e., invasion and worse biochemical recurrence (BCR) after RP, respectively, in univariate analysis. In contrast, combination of high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs was an independent predictor for pT3 and BCR in multivariate analysis. Biologically this combination was also independently associated with suppression of apoptosis. Thus, the co-expression of SSEA-4 in cancer cells and TICs may have crucial roles in the malignant aggressiveness and prognosis of PC. Invasive potential and suppression of apoptosis may be linked to SSEA-4 expression.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Springer Nature
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47508
識別子タイプ HDL
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s10719-019-09882-2
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s10719-019-09882-2
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1573-4986
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0282-0080
収録物名
言語 en
収録物名 Glycoconjugate Journal
書誌情報
巻 36, 号 5, p. 409-418, 発行日 2019-06-26
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