@article{oai:u-ryukyu.repo.nii.ac.jp:02011308,
 author = {Nakamura, Yuichiro and Miyata, Yasuyoshi and Matsuo, Tomohiro and Shida, Yohei and Hakariya, Tomoaki and Ohba, Kojiro and Taima, Takenobu and Ito, Akihiro and Suda, Tetsuji and Hakomori, Sen-itiroh and Saito, Seiichi and Sakai, Hideki},
 issue = {5},
 journal = {Glycoconjugate Journal},
 month = {Jun},
 note = {Stage-specific embryonic antigen-4 (SSEA-4), a specific marker for pluripotent stem cells, plays an important role in the malignant behavior of several cancers. Here, SSEA-4 expression was evaluated by immunohistochemistry using monoclonal antibody RM1 specific to SSEA-4 in 181 and 117 prostate cancer (PC) specimens obtained by biopsy and radical prostatectomy (RP), respectively. The relationships between SSEA-4 expression in cancer cells or the presence of SSEA-4-positive tumor-infiltrating immune cells (TICs) and clinicopathological parameters were analyzed. SSEA-4 expression in cancer cells was significantly associated with Gleason score, local progression, and lymph node and distant metastasis. In RP specimens, high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs were significant predictors of pT3, i.e., invasion and worse biochemical recurrence (BCR) after RP, respectively, in univariate analysis. In contrast, combination of high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs was an independent predictor for pT3 and BCR in multivariate analysis. Biologically this combination was also independently associated with suppression of apoptosis. Thus, the co-expression of SSEA-4 in cancer cells and TICs may have crucial roles in the malignant aggressiveness and prognosis of PC. Invasive potential and suppression of apoptosis may be linked to SSEA-4 expression., 論文},
 pages = {409--418},
 title = {Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer},
 volume = {36},
 year = {2019}
}