{"created":"2022-02-01T06:41:21.090429+00:00","id":2011308,"links":{},"metadata":{"_buckets":{"deposit":"98541370-24a7-4cb6-8268-aab851d1dacd"},"_deposit":{"id":"2011308","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2011308"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02011308","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakamura, Yuichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miyata, Yasuyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsuo, Tomohiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shida, Yohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hakariya, Tomoaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohba, Kojiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Taima, Takenobu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ito, Akihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suda, Tetsuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hakomori, Sen-itiroh","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Saito, Seiichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sakai, Hideki","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"en","subitem_1522651041219":"Creative Commons Attribution 4.0"},{"subitem_1522650717957":"en","subitem_1522650727486":"https://creativecommons.org/licenses/by/4.0/","subitem_1522651041219":"https://creativecommons.org/licenses/by/4.0/"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"SSEA-4"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Tumor-infiltrating immune cells"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Biochemical recurrence"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"Apoptosis · prostate cancer"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Stage-specific embryonic antigen-4 (SSEA-4), a specific marker for pluripotent stem cells, plays an important role in the malignant behavior of several cancers. Here, SSEA-4 expression was evaluated by immunohistochemistry using monoclonal antibody RM1 specific to SSEA-4 in 181 and 117 prostate cancer (PC) specimens obtained by biopsy and radical prostatectomy (RP), respectively. The relationships between SSEA-4 expression in cancer cells or the presence of SSEA-4-positive tumor-infiltrating immune cells (TICs) and clinicopathological parameters were analyzed. SSEA-4 expression in cancer cells was significantly associated with Gleason score, local progression, and lymph node and distant metastasis. In RP specimens, high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs were significant predictors of pT3, i.e., invasion and worse biochemical recurrence (BCR) after RP, respectively, in univariate analysis. In contrast, combination of high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs was an independent predictor for pT3 and BCR in multivariate analysis. Biologically this combination was also independently associated with suppression of apoptosis. Thus, the co-expression of SSEA-4 in cancer cells and TICs may have crucial roles in the malignant aggressiveness and prognosis of PC. Invasive potential and suppression of apoptosis may be linked to SSEA-4 expression.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"Springer Nature"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/47508"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1573-4986"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0282-0080"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"Glycoconjugate Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"418","bibliographicPageStart":"409","bibliographicVolumeNumber":"36"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1007/s10719-019-09882-2"}},{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1007/s10719-019-09882-2"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"Nakamura2019_Article_Stage-specificEmbryonicAntigen.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2011308/files/Nakamura2019_Article_Stage-specificEmbryonicAntigen.pdf"},"version_id":"461beee2-3092-4009-85e9-9d3b88682086"}]},"item_title":"Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer","item_type_id":"15","owner":"1","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-16"},"publish_date":"2020-12-16","publish_status":"0","recid":"2011308","relation_version_is_last":true,"title":["Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-03T05:32:56.466501+00:00"}