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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing α_νβ_3 integrin in chick embryo and nude mouse models

http://hdl.handle.net/20.500.12000/47547
http://hdl.handle.net/20.500.12000/47547
3775cdf8-c293-4df8-8d90-9c5e956fb84d
名前 / ファイル ライセンス アクション
13497-206561-4-PB.pdf 13497-206561-4-PB.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-12-21
タイトル
タイトル The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing α_νβ_3 integrin in chick embryo and nude mouse models
言語 ja
作成者 Tome, Yasunori

× Tome, Yasunori

en Tome, Yasunori

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Kimura, Hiroaki

× Kimura, Hiroaki

en Kimura, Hiroaki

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Sugimoto, Naotoshi

× Sugimoto, Naotoshi

en Sugimoto, Naotoshi

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Tsuchiya, Hiroyuki

× Tsuchiya, Hiroyuki

en Tsuchiya, Hiroyuki

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Kanaya, Fuminori

× Kanaya, Fuminori

en Kanaya, Fuminori

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Bouvet, Michael

× Bouvet, Michael

en Bouvet, Michael

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Hoffman, Robert M.

× Hoffman, Robert M.

en Hoffman, Robert M.

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution 3.0
権利情報
言語 en
権利情報Resource https://creativecommons.org/licenses/by/3.0/
権利情報 https://creativecommons.org/licenses/by/3.0/
主題
言語 ja
主題Scheme Other
主題 α_vβ_3 integrin
主題
言語 en
主題Scheme Other
主題 echistatin
主題
言語 en
主題Scheme Other
主題 green fluorescent protein
主題
言語 en
主題Scheme Other
主題 red fluorescent protein
主題
言語 en
主題Scheme Other
主題 osteosarcoma
主題
言語 en
主題Scheme Other
主題 nude mice
主題
言語 en
主題Scheme Other
主題 orthotopic
内容記述
内容記述タイプ Other
内容記述 Echistatin, a cyclic RGD peptide, which is an antagonist of α_vβ_3 integrin (disintegrin), inhibited human osteosarcoma in the chick chorioallontoic membrane (CAM) model and tumor growth and pulmonary metastases in a nude mouse orthotopic model. A high-metastatic variant of human osteosarcoma, 143B-LM4, overexpressing α_vβ_3 integrin was used. Tumor angiogenesis by high-metastatic variant 143B-LM4 cells in the CAM was significantly inhibited by echistatin (P<0.05) as was overall growth. A doxorubicin (DOX)-echistatin combination inhibited orthotopic tumor growth compared to untreated control (P<0.01) or DOX alone (P<0.05) in nude mice. Tumor-bearing mice treated with the DOX-echistatin combination survived longer than those treated with DOX alone or control PBS (P<0.01 and P<0.01, respectively). Echistatin also inhibited experimental lung metastasis of 143B-LM4 cells in nude mice. These results suggest that DOX in combination with a disintegrin has potential to treat osteosarcoma and that α_vβ_3 integrin may be a target for osteosarcoma.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Impact Journals
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47547
識別子タイプ HDL
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.18632/oncotarget.13497
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.18632/oncotarget.13497
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1949-2553
収録物名
言語 en
収録物名 Oncotarget
書誌情報
巻 7, 号 52, p. 87031-87036, 発行日 2016-11-22
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