@article{oai:u-ryukyu.repo.nii.ac.jp:02011318,
 author = {Tome, Yasunori and Kimura, Hiroaki and Kiyuna, Tasuku and Sugimoto, Naotoshi and Tsuchiya, Hiroyuki and Kanaya, Fuminori and Bouvet, Michael and Hoffman, Robert M.},
 issue = {29},
 journal = {Oncotarget},
 month = {Jun},
 note = {The in vitro efficacy of the disintegrin echistatin was tested on a high-metastatic variant of 143B human osteosarcoma, 143B-LM4, which over-expresses α_vβ_3 integrin. Echistatin is an RGD cyclic peptide and an antagonist of α_vβ_3 integrin. In the present study, echistatin inhibited cell proliferation, migration, invasion, and adhesion of 143B-LM4 cells. 143B-LM4 cell proliferation decreased after treatment with echistatin in a time-dependent and dose-dependent manner (P <0.01). In vitro migration and invasion of 143B-LM4 cells were also inhibited by echistatin in a dose-dependent manner (P <0.01, respectively). Cell adhesion to vitronectin of 143B-LM4 cells was also inhibited by echistatin in a dose-dependent manner (P <0.01). These results suggest that α_vβ_3 integrin may be an effective target for osteosarcoma., 論文},
 pages = {46315--46320},
 title = {Disintegrin targeting of an α_vβ_3 integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro},
 volume = {7},
 year = {2016}
}