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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

T Cell Receptor Vβ Staining Identifies the Malignant Clone in Adult T cell Leukemia and Reveals Killing of Leukemia Cells by Autologous CD8^+ T cells

http://hdl.handle.net/20.500.12000/45207
http://hdl.handle.net/20.500.12000/45207
0a97cabe-7f7b-41ce-9c02-794cdbd0caea
名前 / ファイル ライセンス アクション
No12p1.pdf No12p1.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-01-16
タイトル
タイトル T Cell Receptor Vβ Staining Identifies the Malignant Clone in Adult T cell Leukemia and Reveals Killing of Leukemia Cells by Autologous CD8^+ T cells
言語 ja
作成者 Rowan, Aileen G.

× Rowan, Aileen G.

en Rowan, Aileen G.

Witkover, Aviva

× Witkover, Aviva

en Witkover, Aviva

Melamed, Anat

× Melamed, Anat

en Melamed, Anat

Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

Cook, Lucy B. M.

× Cook, Lucy B. M.

en Cook, Lucy B. M.

Fields, Paul

× Fields, Paul

en Fields, Paul

Taylor, Graham P.

× Taylor, Graham P.

en Taylor, Graham P.

Bangham, Charles R. M.

× Bangham, Charles R. M.

en Bangham, Charles R. M.

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
内容記述
内容記述タイプ Other
内容記述 There is growing evidence that CD8^+ cytotoxic T lymphocyte (CTL) responses can contribute to long-term remission of many malignancies. The etiological agent of adult T-cell leukemia/lymphoma (ATL), human T lymphotropic virus type-1 (HTLV-1), contains highly immunogenic CTL epitopes, but ATL patients typically have low frequencies of cytokine-producing HTLV-1-specific CD8^+ cells in the circulation. It remains unclear whether patients with ATL possess CTLs that can kill the malignant HTLV-1 infected clone. Here we used flow cytometric staining of TCRVβ and cell adhesion molecule-1 (CADM1) to identify monoclonal populations of HTLV-1-infected T cells in the peripheral blood of patients with ATL. Thus, we quantified the rate of CD8^+-mediated killing of the putative malignant clone in ex vivo blood samples. We observed that CD8^+ cells from ATL patients were unable to lyse autologous ATL clones when tested directly ex vivo. However, short in vitro culture restored the ability of CD8^+ cells to kill ex vivo ATL clones in some donors. The capacity of CD8^+ cells to lyse HTLV-1 infected cells which expressed the viral sense strand gene products was significantly enhanced after in vitro culture, and donors with an ATL clone that expressed the HTLV-1 Tax gene were most likely to make a detectable lytic CD^8+ response to the ATL cells. We conclude that some patients with ATL possess functional tumour-specific CTLs which could be exploited to contribute to control of the disease.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Public Library of Science
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/45207
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.ppat.1006030
関連識別子
識別子タイプ DOI
関連識別子 10.1371/journal.ppat.1006030
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1553-7366
収録物識別子タイプ ISSN
収録物識別子 1553-7374
収録物識別子タイプ NCID
収録物識別子 AA12072310
収録物名
言語 en
収録物名 PLoS Pathogens
書誌情報
巻 12, 号 11, p. 1-20
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