@article{oai:u-ryukyu.repo.nii.ac.jp:02012285,
 author = {Enose-Akahata, Yoshimi and Azodi, Shila and Smith, Bryan R. and Billioux, Bridgette Jeanne and Vellucci, Ashley and Ngouth, Nyater and Tanaka, Yuetsu and Ohayon, Joan and Cortese, Irene and Nath, Avindra and Jacobson, Steven},
 issue = {4},
 journal = {PLOS Pathogens},
 month = {Apr},
 note = {Intrathecal antibody synthesis is a well-documented phenomenon in infectious neurological diseases as well as in demyelinating diseases, but little is known about the role of B cells in the central nervous systems. We examined B cell and T cell immunophenotypes in CSF of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) compared to healthy normal donors and subjects with the other chronic virus infection and/or neuroinflammatory diseases including HIV infection, multiple sclerosis (MS) and progressive multifocal leukoencephalopathy. Antibody secreting B cells (ASCs) were elevated in HAM/TSP patients, which was significantly correlated with intrathecal HTLV-1-specific antibody responses. High frequency of ASCs was also detected in patients with relapsing-remitting multiple sclerosis (RRMS). While RRMS patients showed significant correlations between ASCs and memory follicular helper CD4+ T cells, CD4+CD25+ T cells were elevated in HAM/TSP patients, which were significantly correlated with ASCs and HTLV-1 proviral load. These results highlight the importance of the B cell compartment and the associated inflammatory milieu in HAM/TSP patients where virus-specific antibody production may be required to control viral persistence and/or may be associated with disease development., 論文},
 title = {Immunophenotypic characterization of CSF B cells in virus-associated neuroinflammatory diseases},
 volume = {14},
 year = {2018}
}