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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells

http://hdl.handle.net/20.500.12000/45872
http://hdl.handle.net/20.500.12000/45872
47b547e4-628b-4511-9ffa-22cbd9ebc933
名前 / ファイル ライセンス アクション
cas.12618.pdf cas.12618.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-05-22
タイトル
タイトル Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells
言語 en
作成者 Takachi, Takayuki

× Takachi, Takayuki

en Takachi, Takayuki

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Takahashi, Masahiko

× Takahashi, Masahiko

en Takahashi, Masahiko

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Takahashi-Yoshita, Manami

× Takahashi-Yoshita, Manami

en Takahashi-Yoshita, Manami

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Higuchi, Masaya

× Higuchi, Masaya

en Higuchi, Masaya

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Obata, Miki

× Obata, Miki

en Obata, Miki

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Mishima, Yukio

× Mishima, Yukio

en Mishima, Yukio

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Okuda, Shujiro

× Okuda, Shujiro

en Okuda, Shujiro

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Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

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Matsuoka, Masao

× Matsuoka, Masao

en Matsuoka, Masao

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Saitoh, Akihiro

× Saitoh, Akihiro

en Saitoh, Akihiro

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Green, Patrick L.

× Green, Patrick L.

en Green, Patrick L.

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Fuji, Masahiro

× Fuji, Masahiro

en Fuji, Masahiro

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Licens Attribution-NonCommercial-NoDerivatives 4.0
権利情報
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 https://creativecommons.org/licenses/by-nc-nd/4.0/
主題
言語 en
主題Scheme Other
主題 Adult T cell leukemia
主題
言語 en
主題Scheme Other
主題 BCL11B
主題
言語 en
主題Scheme Other
主題 HBZ
主題
言語 en
主題Scheme Other
主題 HTLV-1
主題
言語 en
主題Scheme Other
主題 Tax
内容記述
内容記述タイプ Other
内容記述 Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T cell leukemia (ATL), which is an aggressive form of T-cell malignancy. HTLV-1 oncoproteins, Tax and HBZ, play crucial roles in the immortalization of T-cells and/or leukemogenesis by dysregulating the cellular functions in the host. Recent studies show that HTLV-1-infected T-cells have reduced expression of the BCL11B tumor suppressor protein. In the present study, we explored whether Tax and/or HBZ play a role in downregulating BCL11B in HTLV-1-infected T-cells. Lentiviral transduction of Tax in a human T-cell line repressed the expression of BCL11B at both the protein and mRNA levels, whereas the transduction of HBZ had little effect on the expression. Tax mutants with a decreased activity for the NF-B, CREB or PDZ protein pathways still showed a reduced expression of the BCL11B protein, thereby implicating a different function of Tax in BCL11B downregulation. In addition, the HTLV-2 Tax2 protein reduced the BCL11B protein expression in T-cells. Seven HTLV-1-infected T-cell lines, including three ATL-derived cell lines, showed reduced BCL11B mRNA and protein expression relative to an uninfected T-cell line, and the greatest reductions were in the cells expressing Tax. Collectively, these results indicate that Tax is responsible for suppressing BCL11B protein expression in HTLV-1-infected T-cells; Tax-mediated repression of BCL11B is another mechanism that Tax uses to promote oncogenesis of HTLV-1-infected T-cells.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/45872
識別子タイプ HDL
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/cas.12618
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/cas.12618
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1347-9032
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1349-7006
収録物名
言語 en
収録物名 Cancer science
書誌情報
巻 106, 号 4, p. 461-465, 発行日 2015-04
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