{"created":"2022-02-02T02:07:24.812413+00:00","id":2012376,"links":{},"metadata":{"_buckets":{"deposit":"a0db4708-6f05-4565-80f1-cbf68efbc015"},"_deposit":{"id":"2012376","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2012376"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02012376","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamagishi, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hori, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fujikawa, Dai","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohsugi, Takeo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Honma, Daisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Adachi, Nobuaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Katano, Harutaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hishima, Tsunekazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kobayashi, Seiichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakano, Kazumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakashima, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iwanaga, Masako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Utsunomiya, Atae","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Yuetsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okada, Seiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tsukasaki, Kunihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tobinai, Kensei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Araki, Kazushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Watanabe, Toshiki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Uchimaru, Kaoru","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"en","subitem_1522651041219":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0"},{"subitem_1522650717957":"en","subitem_1522650727486":"https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_1522651041219":"https://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Although global H3K27me3 reprogramming is a hallmark of cancer, no effective therapeutic strategy for H3K27me3-high malignancies harboring EZH2(WT/WT) has yet been established. We explore epigenome and transcriptome in EZH2(WT/WT) and EZH2(WT/Mu) aggressive lymphomas and show that mutual interference and compensatory function of co-expressed EZH1 and EZH2 rearrange their own genome-wide distribution, thereby establishing restricted chromatin and gene expression signatures. Direct comparison of leading compounds introduces potency and a mechanism of action of the EZH1/2 dual inhibitor (valemetostat). The synthetic lethality is observed in all lymphoma models and primary adult T cell leukemia-lymphoma (ATL) cells. Opposing actions of EZH1/2-polycomb and SWI/SNF complexes are required for facultative heterochromatin formation. Inactivation of chromatin-associated genes (ARID1A, SMARCA4/BRG1, SMARCB1/SNF5, KDM6A/UTX, BAP1, KMT2D/MLL2) and oncovirus infection (HTLV-1, EBV) trigger EZH1/2 perturbation and H3K27me3 deposition. Our study provides the mechanism-based rationale for chemical dual targeting of EZH1/2 in cancer epigenome.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"Cell Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/45873"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"2211-1247"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"Cell reports"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11-19","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"2337","bibliographicPageStart":"2321","bibliographicVolumeNumber":"29"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1016/j.celrep.2019.10.083"}},{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1016/j.celrep.2019.10.083"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"PIIS2211124719314056.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2012376/files/PIIS2211124719314056.pdf"},"version_id":"9620c13f-0c2a-48f4-a316-52359dd7b931"}]},"item_title":"Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas","item_type_id":"15","owner":"1","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-05-22"},"publish_date":"2020-05-22","publish_status":"0","recid":"2012376","relation_version_is_last":true,"title":["Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-03T05:31:09.860530+00:00"}