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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia

http://hdl.handle.net/20.500.12000/45888
http://hdl.handle.net/20.500.12000/45888
c26f0ee9-50d8-41d8-91ae-902f41aaf9f2
名前 / ファイル ライセンス アクション
emmm.201506154.pdf emmm.201506154.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-05-26
タイトル
タイトル OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia
言語 en
作成者 Hirano, Taizou

× Hirano, Taizou

en Hirano, Taizou

Kikuchi, Toshiaki

× Kikuchi, Toshiaki

en Kikuchi, Toshiaki

Tode, Naoki

× Tode, Naoki

en Tode, Naoki

Santoso, Arif

× Santoso, Arif

en Santoso, Arif

Yamada, Mitsuhiro

× Yamada, Mitsuhiro

en Yamada, Mitsuhiro

Mitsuhashi, Yoshiya

× Mitsuhashi, Yoshiya

en Mitsuhashi, Yoshiya

Komatsu, Riyo

× Komatsu, Riyo

en Komatsu, Riyo

Kawabe, Takeshi

× Kawabe, Takeshi

en Kawabe, Takeshi

Tanimoto, Takeshi

× Tanimoto, Takeshi

en Tanimoto, Takeshi

Ishii, Naoto

× Ishii, Naoto

en Ishii, Naoto

Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

Nishimura, Hidekazu

× Nishimura, Hidekazu

en Nishimura, Hidekazu

Nukiwa, Toshihiro

× Nukiwa, Toshihiro

en Nukiwa, Toshihiro

Watanabe, Akira

× Watanabe, Akira

en Watanabe, Akira

Ichinose, Masakazu

× Ichinose, Masakazu

en Ichinose, Masakazu

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 https://creativecommons.org/licenses/by/4.0/
主題
言語 en
主題Scheme Other
主題 bronchioles
言語 en
主題Scheme Other
主題 glycosylation regeneration
言語 en
主題Scheme Other
主題 OX40 ligand
言語 en
主題Scheme Other
主題 viralpneumonia
内容記述
内容記述タイプ Other
内容記述 Influenza virus epidemics potentially cause pneumonia, which is responsible for much of the mortality due to the excessive immune responses. The role of costimulatory OX40-OX40 ligand (OX40L) interactions has been explored in the non-infectious pathology of influenza pneumonia. Here, we describe a critical contribution of OX40L to infectious pathology, with OX40L deficiency, but not OX40 deficiency, resulting in decreased susceptibility to influenza viral infection. Upon infection, bronchiolar progenitors increase in number for repairing the influenza-damaged epithelia. The OX40L expression is induced on the progenitors for the antiviral immunity during the infectious process. However, these defense-like host responses lead to more extensive infection owing to the induced OX40L with -2,6 sialic acid modification, which augments the interaction with the viral hemagglutinin. In fact, the specific antibody against the sialylated site of OX40L exhibited therapeutic potency in mitigating the OX40L-mediated susceptibility to influenza. Our data illustrate that the influenza-induced expression of OX40L on bronchiolar progenitors has pathogenic value to develop a novel therapeutic approach against influenza.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 EMBO press
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/45888
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.15252/emmm.201506154
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.15252/emmm.201506154
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1757-4684
収録物識別子タイプ ISSN
収録物識別子 1757-4676
収録物名
言語 en
収録物名 EMBO Molecular Medicine
書誌情報
巻 8, 号 4, p. 422-436
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