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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Computed tomography–based image-guided brachytherapy for cervical cancer : correlations between dose–volume parameters and clinical outcomes

http://hdl.handle.net/20.500.12000/45946
http://hdl.handle.net/20.500.12000/45946
6e9700fb-aff5-4ec5-8aa3-9ba2af6effc7
名前 / ファイル ライセンス アクション
rrx065.pdf rrx065.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-05-29
タイトル
タイトル Computed tomography–based image-guided brachytherapy for cervical cancer : correlations between dose–volume parameters and clinical outcomes
言語 ja
作成者 Kusada, Takeaki

× Kusada, Takeaki

en Kusada, Takeaki

Toita, Takafumi

× Toita, Takafumi

en Toita, Takafumi

Ariga, Takuro

× Ariga, Takuro

en Ariga, Takuro

Maemoto, Hitoshi

× Maemoto, Hitoshi

en Maemoto, Hitoshi

Hashimoto, Seiji

× Hashimoto, Seiji

en Hashimoto, Seiji

Shiina, Hideki

× Shiina, Hideki

en Shiina, Hideki

Kakinohana, Yasumasa

× Kakinohana, Yasumasa

en Kakinohana, Yasumasa

Joichi, Heianna

× Joichi, Heianna

en Joichi, Heianna

Nagai, Yutaka

× Nagai, Yutaka

en Nagai, Yutaka

Kudaka, Wataru

× Kudaka, Wataru

en Kudaka, Wataru

Aoki, Youichi

× Aoki, Youichi

en Aoki, Youichi

Murayama, Sadayuki

× Murayama, Sadayuki

en Murayama, Sadayuki

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution-NonCommercial 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc/4.0/
権利情報 https://creativecommons.org/licenses/by-nc/4.0/
主題
言語 en
主題Scheme Other
主題 cervical neoplasms
言語 en
主題Scheme Other
主題 image-guided brachytherapy
言語 en
主題Scheme Other
主題 computed tomography
言語 en
主題Scheme Other
主題 high-risk clinical target volume
内容記述
内容記述タイプ Other
内容記述 This study evaluated the oncologic outcomes and complications of cervical cancer patients in terms of CT-based image-guided brachytherapy (IGBT) parameters. Of 68 cervical cancer patients treated with definitive radiotherapy/concurrent chemoradiotherapy, most received whole-pelvis external beam RT (EBRT) of 40 Gy in 20 fractions, pelvic EBRT with central shield of 10 Gy in 5 fractions, and CT-based IGBT of 18 Gy in 3 fractions prescribed to point A. Cumulative EBRT and IGBT doses were calculated as the total equivalent dose in 2 Gy fractions (EQD2). The median follow-up was 31 (3–52) months. The 2-year overall survival, local control, pelvic control, and disease-free survival rates of the 68 patients were 92%, 83%, 82% and 73%, respectively. The HR-CTV D90, length from the tandem axis to left/right margin of the HR-CTV (T-LR), and HR-CTV volume were significant IGBT parameters for predicting local/pelvic control. Patients who received an HR-CTV D90 of >60 Gy, compared with ≤60 Gy, had significantly better local/pelvic control. Furthermore, 70 Gy was a marginally significant HR-CTV D90 cut-off affecting local control. T-LR was an independent IGBT parameter predicting local/pelvic control on multivariate analysis. Three patients developed Grade 3 or higher treatment-related complications. The D2cm3 of organs at risk were not significant predictors of complications. Future challenges for further improving outcomes include additional interstitial needles for irregularly shaped HR-CTVs, and moderate dose escalation, especially for patients with poor tumor responses.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/45946
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/jrr/rrx065
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/jrr/rrx065
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0449-3060
収録物識別子タイプ ISSN
収録物識別子 1349-9157
収録物名
言語 en
収録物名 Journal of Radiation Research
書誌情報
巻 59, 号 1, p. 67-76
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