{"created":"2022-02-02T02:08:02.321989+00:00","id":2012395,"links":{},"metadata":{"_buckets":{"deposit":"daedb105-dd54-4eec-8335-55e95aedffa3"},"_deposit":{"id":"2012395","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2012395"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02012395","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Computed tomography–based image-guided brachytherapy for cervical cancer : correlations between dose–volume parameters and clinical outcomes","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kusada, Takeaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Toita, Takafumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ariga, Takuro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Maemoto, Hitoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hashimoto, Seiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shiina, Hideki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kakinohana, Yasumasa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Joichi, Heianna","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagai, Yutaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kudaka, Wataru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Aoki, Youichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Murayama, Sadayuki","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"en","subitem_1522651041219":"Creative Commons Attribution-NonCommercial 4.0"},{"subitem_1522650717957":"en","subitem_1522650727486":"https://creativecommons.org/licenses/by-nc/4.0/","subitem_1522651041219":"https://creativecommons.org/licenses/by-nc/4.0/"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"cervical neoplasms"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"image-guided brachytherapy"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"computed tomography"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"high-risk clinical target volume"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"This study evaluated the oncologic outcomes and complications of cervical cancer patients in terms of CT-based image-guided brachytherapy (IGBT) parameters. Of 68 cervical cancer patients treated with definitive radiotherapy/concurrent chemoradiotherapy, most received whole-pelvis external beam RT (EBRT) of 40 Gy in 20 fractions, pelvic EBRT with central shield of 10 Gy in 5 fractions, and CT-based IGBT of 18 Gy in 3 fractions prescribed to point A. Cumulative EBRT and IGBT doses were calculated as the total equivalent dose in 2 Gy fractions (EQD2). The median follow-up was 31 (3–52) months. The 2-year overall survival, local control, pelvic control, and disease-free survival rates of the 68 patients were 92%, 83%, 82% and 73%, respectively. The HR-CTV D90, length from the tandem axis to left/right margin of the HR-CTV (T-LR), and HR-CTV volume were significant IGBT parameters for predicting local/pelvic control. Patients who received an HR-CTV D90 of >60 Gy, compared with ≤60 Gy, had significantly better local/pelvic control. Furthermore, 70 Gy was a marginally significant HR-CTV D90 cut-off affecting local control. T-LR was an independent IGBT parameter predicting local/pelvic control on multivariate analysis. Three patients developed Grade 3 or higher treatment-related complications. The D2cm3 of organs at risk were not significant predictors of complications. Future challenges for further improving outcomes include additional interstitial needles for irregularly shaped HR-CTVs, and moderate dose escalation, especially for patients with poor tumor responses.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"Oxford University Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/45946"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0449-3060"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1349-9157"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"Journal of Radiation Research"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"76","bibliographicPageStart":"67","bibliographicVolumeNumber":"59"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1093/jrr/rrx065"}},{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1093/jrr/rrx065"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"rrx065.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2012395/files/rrx065.pdf"},"version_id":"a876506d-7835-419c-a612-9be4e494496c"}]},"item_title":"Computed tomography–based image-guided brachytherapy for cervical cancer : correlations between dose–volume parameters and clinical outcomes","item_type_id":"15","owner":"1","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-05-29"},"publish_date":"2020-05-29","publish_status":"0","recid":"2012395","relation_version_is_last":true,"title":["Computed tomography–based image-guided brachytherapy for cervical cancer : correlations between dose–volume parameters and clinical outcomes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-03T05:43:20.755345+00:00"}