{"created":"2022-02-02T02:08:23.180963+00:00","id":2012404,"links":{},"metadata":{"_buckets":{"deposit":"32df6cdb-a77f-4699-a058-1c574d426a84"},"_deposit":{"id":"2012404","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2012404"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02012404","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Pseudotyping of HIV-1 with Human T-Lymphotropic Virus 1 (HTLV-1) Envelope Glycoprotein during HIV-1–HTLV-1 Coinfection Facilitates Direct HIV-1 Infection of Female Genital Epithelial Cells : Implications for Sexual Transmission of HIV-1","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tang, Yuyang","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"George, Alvin M.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Petrechko, Oksana","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nouvet, Franklin J.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sweet, Stephanie D.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Yuetsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Imbiakha, Brian S.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Jiang, Guochun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Gao, Wei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Anastos, Kathryn","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hildreth, James E.K.","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"en","subitem_1522651041219":"Creative Commons Attribution 4.0"},{"subitem_1522650717957":"en","subitem_1522650727486":"https://creativecommons.org/licenses/by/4.0/","subitem_1522651041219":"https://creativecommons.org/licenses/by/4.0/"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"envelope glycoprotein"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"epithelial cells"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"human T-cell leukemia virus"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"human immunodeficiency virus"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"primary T-cells"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"pseudotype"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"retroviruses"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"sexual transmission"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"virus tropism"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Female genital epithelial cells cover the genital tract and provide the first line of protection against infection with sexually transmitted pathogenic viruses. These cells normally are impervious to HIV-1. We report that coinfection of cells by HIV-1 and another sexually transmitted virus, human T-lymphotropic virus 1 (HTLV-1), led to production of HIV-1 that had expanded cell tropism and was able to directly infect primary vaginal and cervical epithelial cells. HIV-1 infection of epithelial cells was blocked by neutralizing antibodies against the HTLV-1 envelope (Env) protein, indicating that the infection was mediated through HTLV-1 Env pseudotyping of HIV-1. Active replication of HIV-1 in epithelial cells was demonstrated by inhibition with anti-HIV-1 drugs. We demonstrated that HIV-1 derived from peripheral blood of HIV-1–HTLV-1-coinfected subjects could infect primary epithelial cells in an HTLV-1 Env-dependent manner. HIV-1 from subjects infected with HIV-1 alone was not able to infect epithelial cells. These results indicate that pseudotyping of HIV-1 with HTLV-1 Env can occur in vivo. Our data further reveal that active replication of both HTLV-1 and HIV-1 is required for production of pseudotyped HIV-1. Our findings indicate that pseudotyping of HIV-1 with HTLV-1 Env in coinfected cells enabled HIV-1 to directly infect nonpermissive female genital epithelial cells. This phenomenon may represent a risk factor for enhanced sexual transmission of HIV-1 in regions where virus coinfection is common.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"American Society for Microbiology Journals"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/45973"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"2379-5042"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"mSphere"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicVolumeNumber":"3"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1128/mSphere.00038-18"}},{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1128/mSphere.00038-18"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"mSphere-2018-Tang-e00038-18.full.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2012404/files/mSphere-2018-Tang-e00038-18.full.pdf"},"version_id":"326d8aad-79ec-4efa-b9b4-2a377600445b"}]},"item_title":"Pseudotyping of HIV-1 with Human T-Lymphotropic Virus 1 (HTLV-1) Envelope Glycoprotein during HIV-1–HTLV-1 Coinfection Facilitates Direct HIV-1 Infection of Female Genital Epithelial Cells : Implications for Sexual Transmission of HIV-1","item_type_id":"15","owner":"1","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-02"},"publish_date":"2020-06-02","publish_status":"0","recid":"2012404","relation_version_is_last":true,"title":["Pseudotyping of HIV-1 with Human T-Lymphotropic Virus 1 (HTLV-1) Envelope Glycoprotein during HIV-1–HTLV-1 Coinfection Facilitates Direct HIV-1 Infection of Female Genital Epithelial Cells : Implications for Sexual Transmission of HIV-1"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-03T05:25:15.544089+00:00"}