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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Intranasal sensitization with Blomia Tropicalis antigens induces allergic responses in mice characterized by elevated antigen-specific and non-specific serum ige and peripheral blood eosinophil counts

http://hdl.handle.net/20.500.12000/46018
http://hdl.handle.net/20.500.12000/46018
963b6fbf-d6cd-4e2c-b217-c25bb5009a5e
名前 / ファイル ライセンス アクション
v46n1a01.pdf v46n1a01.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-06-03
タイトル
タイトル Intranasal sensitization with Blomia Tropicalis antigens induces allergic responses in mice characterized by elevated antigen-specific and non-specific serum ige and peripheral blood eosinophil counts
言語 en
作成者 Takeda, Fumiko

× Takeda, Fumiko

en Takeda, Fumiko

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Arakawa, Takeshi

× Arakawa, Takeshi

en Arakawa, Takeshi

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Toma, Hiromu

× Toma, Hiromu

en Toma, Hiromu

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Ishii, Akiro

× Ishii, Akiro

en Ishii, Akiro

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Sato, Yoshiya

× Sato, Yoshiya

en Sato, Yoshiya

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution-NonCommercial 4.0
権利情報
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc/4.0/
権利情報 https://creativecommons.org/licenses/by-nc/4.0/
主題
言語 en
主題Scheme Other
主題 Mite
主題
言語 en
主題Scheme Other
主題 Blomia tropicalis
主題
言語 en
主題Scheme Other
主題 Intranasal sensitization
主題
言語 en
主題Scheme Other
主題 Mucosal adjuvant
内容記述
内容記述タイプ Other
内容記述 In order to evaluate the potential allergenicity of Blomia tropicalis (Bt) antigen, IgE production of both specific and non-specific for Bt antigen was monitored in BALB/c mice after exposure to the antigen by nasal route. It was evidenced that B. tropicalis contains a functional allergen in its components. The allergenic components, however, when administered intranasally without any adjuvant, did not function to induce IgE response within a short period. On the other hand, intranasal inoculation of Bt antigens augmented serum IgE responses in mice pretreated by a subcutaneous priming injection of the same antigens. Inoculation of Bt antigen without subcutaneous priming injections induced IgE antibody production only when the antigen was continuously administered for a long period of over 24 weeks. Even when the priming injection was absent, the Bt antigen inoculated with cholera toxin (CT) as a mucosal adjuvant also significantly augmented the Bt antigen-specific IgE responses depending on the dose of CT co-administered. The present study also demonstrated that Bt antigen/CT-inoculated mice showed increased non-specific serum IgE level and peripheral blood eosinophil rates without noticeable elevations of the total leukocyte counts. The immunoblot analysis demonstrated 5 main antigenic components reactive to IgE antibodies induced. These components at about 44-64 kDa position were considered to be an important candidate antigen for diagnosis of the mite-related allergy.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Scientific Electronic Library Online
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/46018
識別子タイプ HDL
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1590/S0036-46652004000100001
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1590/S0036-46652004000100001
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0036-4665
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1678-9946
収録物名
言語 ja
収録物名 Revista do Instituto de Medicina Tropical de São Paulo
書誌情報
巻 46, 号 1, p. 1-8, 発行日 2004
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