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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

T cell receptor signaling pathway is overexpressed in CD4^+ T cells from HAM/TSP individuals

http://hdl.handle.net/20.500.12000/46026
http://hdl.handle.net/20.500.12000/46026
854f601c-c2e0-416a-ba6a-33fc4d07e45e
名前 / ファイル ライセンス アクション
1-s2.0-S1413867015001488-main.pdf 1-s2.0-S1413867015001488-main.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-06-04
タイトル
タイトル T cell receptor signaling pathway is overexpressed in CD4^+ T cells from HAM/TSP individuals
言語 en
作成者 Pinto, Mariana Tomazini

× Pinto, Mariana Tomazini

en Pinto, Mariana Tomazini

Malta, Tathiane Maistro

× Malta, Tathiane Maistro

en Malta, Tathiane Maistro

Rodrigues, Evandra Strazza

× Rodrigues, Evandra Strazza

en Rodrigues, Evandra Strazza

Takayanagui, Osvaldo Massaiti

× Takayanagui, Osvaldo Massaiti

en Takayanagui, Osvaldo Massaiti

Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

Covas, Dimas Tadeu

× Covas, Dimas Tadeu

en Covas, Dimas Tadeu

Kashima, Simone

× Kashima, Simone

en Kashima, Simone

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution-NonCommercial-NoDerivatives 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 https://creativecommons.org/licenses/by-nc-nd/4.0/
主題
言語 en
主題Scheme Other
主題 HTLV-1
言語 en
主題Scheme Other
主題 HAM/TSP
言語 en
主題Scheme Other
主題 CD4^+ T cell activation
言語 en
主題Scheme Other
主題 Gene expression
内容記述
内容記述タイプ Other
内容記述 Human T-lymphotropic virus type 1 (HTLV-1) is a human retrovirus related to the chronic neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4^+ T cells activation appears to play a key role on HTLV-1 infection. Here we investigated the expression of genes associated to T cell activation CD3e molecule, epsilon (CD3ɛ), lymphocyte-specific protein tyrosine kinase (LCK), vav 1 guanine nucleotide exchange factor (VAV1), and zeta-chain (TCR) associated protein kinase 70 kDa (ZAP70) on T lymphocytes of HTLV-1-infected individuals and compared to healthy uninfected individuals (CT). We observed that CD3ɛ, LCK, ZAP70, and VAV1 gene expression were increased in CD4^+ T cells from HAM/TSP group compared to HTLV-1 asymptomatic patients (HAC). Moreover, ZAP70 and VAV1 were also upregulated in HAM/TSP compared to CT group. We detected a positive correlation among all these genes. We also observed that CD3ɛ, LCK, and VAV1 genes had a positive correlation with the proviral load (PVL) and Tax expression. These results suggest that PVL and Tax protein could drive CD3ɛ, LCK, and VAV1 gene expression in CD4^+ T cells, and these genes function on a synchronized way on the CD4^+ T cell activation. The elucidation of the mechanisms underlying T cell receptor signaling pathway is of considerable interest and might lead to new insights into the mechanism of HAM/TSP.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/46026
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.bjid.2015.07.008
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.bjid.2015.07.008
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1413-8670
収録物識別子タイプ ISSN
収録物識別子 1678-4391
収録物名
言語 en
収録物名 The Brazilian Journal of Infectious Diseases
書誌情報
巻 19, 号 6, p. 578-584
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