@article{oai:u-ryukyu.repo.nii.ac.jp:02012457,
 author = {Pinto, Mariana Tomazini and Malta, Tathiane Maistro and Rodrigues, Evandra Strazza and Takayanagui, Osvaldo Massaiti and Tanaka, Yuetsu and Covas, Dimas Tadeu and Kashima, Simone},
 issue = {6},
 journal = {The Brazilian Journal of Infectious Diseases},
 month = {},
 note = {Human T-lymphotropic virus type 1 (HTLV-1) is a human retrovirus related to the chronic neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4^+ T cells activation appears to play a key role on HTLV-1 infection. Here we investigated the expression of genes associated to T cell activation CD3e molecule, epsilon (CD3ɛ), lymphocyte-specific protein tyrosine kinase (LCK), vav 1 guanine nucleotide exchange factor (VAV1), and zeta-chain (TCR) associated protein kinase 70 kDa (ZAP70) on T lymphocytes of HTLV-1-infected individuals and compared to healthy uninfected individuals (CT). We observed that CD3ɛ, LCK, ZAP70, and VAV1 gene expression were increased in CD4^+ T cells from HAM/TSP group compared to HTLV-1 asymptomatic patients (HAC). Moreover, ZAP70 and VAV1 were also upregulated in HAM/TSP compared to CT group. We detected a positive correlation among all these genes. We also observed that CD3ɛ, LCK, and VAV1 genes had a positive correlation with the proviral load (PVL) and Tax expression. These results suggest that PVL and Tax protein could drive CD3ɛ, LCK, and VAV1 gene expression in CD4^+ T cells, and these genes function on a synchronized way on the CD4^+ T cell activation. The elucidation of the mechanisms underlying T cell receptor signaling pathway is of considerable interest and might lead to new insights into the mechanism of HAM/TSP., 論文},
 pages = {578--584},
 title = {T cell receptor signaling pathway is overexpressed in CD4^+ T cells from HAM/TSP individuals},
 volume = {19},
 year = {2015}
}