{"created":"2022-02-02T02:10:11.003350+00:00","id":2012459,"links":{},"metadata":{"_buckets":{"deposit":"0973dfc7-8982-4c0f-97ed-54ed01ee2028"},"_deposit":{"id":"2012459","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2012459"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02012459","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline : possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Saito, Mineki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sejima, Hiroe","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Naito, Tadasuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ushirogawa, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsuzaki, Toshio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsuura, Eiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Yuetsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamura, Tatsufumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takashima, Hiroshi","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"en","subitem_1522651041219":"Creative Commons Attribution 4.0"},{"subitem_1522650717957":"en","subitem_1522650727486":"https://creativecommons.org/licenses/by/4.0/","subitem_1522651041219":"https://creativecommons.org/licenses/by/4.0/"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"HTLV-1"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Tax"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"CCL1"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"HAM/TSP"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Minocycline"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Background:Chemokine (C-C motif) ligand 1 (CCL1) is produced by activated monocytes/ macrophages and T-lymphocytes, and acts as a potent attractant for Th2 cells and a subset of T-regulatory (Treg) cells. Previous reports have indicated that CCL1 is overexpressed in adult T-cell leukemia cells, mediating an autocrine anti-apoptotic loop. Because CCL1 is also known as a potent chemoattractant that plays a major role in inflammatory processes, we investigated the role of CCL1 in the pathogenesis of human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Results:The results showed that: (1) CCL1 was preferentially expressed in HAM/TSP-derived HTLV-1-infected T-cell lines, (2) CCL1 expression was induced along with Tax expression in the Tax-inducible T-cell line JPX9, (3) transient Tax expression in an HTLV-1-negative T-cell line activated the CCL1 gene promoter, (4) plasma levels of CCL1 were significantly higher in patients with HAM/TSP than in HTLV-1-seronegative patients with multiple sclerosis and HTLV-1-infected asymptomatic healthy carriers, and (5) minocycline inhibited the production of CCL1 in HTLV-1-infected T-cell lines. Conclusions:The present results suggest that elevated CCL1 levels may be associated with the pathogenesis of HAM/TSP. Although further studies are required to determine the in vivo significance, minocycline may be considered as a potential candidate for the long-term treatment of HAM/TSP via its anti-inflammatory effects, which includes the inhibition of CCL1 expression.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"BioMed Central"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/46046"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1743-422X"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"Virology Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12-04","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"14"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1186/s12985-017-0902-6"}},{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1186/s12985-017-0902-6"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"Saito2017_Article_TheCCChemokineLigandCCL1Upregu.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2012459/files/Saito2017_Article_TheCCChemokineLigandCCL1Upregu.pdf"},"version_id":"0b7396df-946e-42ca-af57-70d66d5d45fa"}]},"item_title":"The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline : possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis","item_type_id":"15","owner":"1","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-05"},"publish_date":"2020-06-05","publish_status":"0","recid":"2012459","relation_version_is_last":true,"title":["The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline : possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-03T05:27:19.779326+00:00"}