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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

GABA/glycine signaling during degeneration and regeneration of mouse hypoglossal nerves

http://hdl.handle.net/20.500.12000/46546
http://hdl.handle.net/20.500.12000/46546
38bef046-6f83-4358-9da2-639311486dd8
名前 / ファイル ライセンス アクション
Figure Figure 10.tif
Figure Figure 09.tif
Figure Figure 08.tif
Figure Figure 07.tif
Figure Figure 06.tif
Figure Figure 05.tif
Figure Figure 04.tif
Figure Figure 03.tif
Figure Figure 02.tif
Figure Figure 01.tif
1446.29.pdf 1446.29.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-07-31
タイトル
タイトル GABA/glycine signaling during degeneration and regeneration of mouse hypoglossal nerves
言語 en
作成者 Tatetsu, Masaharu

× Tatetsu, Masaharu

en Tatetsu, Masaharu

Kim, Jeongtae

× Kim, Jeongtae

en Kim, Jeongtae

Kina, Shinichiro

× Kina, Shinichiro

en Kina, Shinichiro

Sunakawa, Hajime

× Sunakawa, Hajime

en Sunakawa, Hajime

Takayama, Chitoshi

× Takayama, Chitoshi

en Takayama, Chitoshi

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution-NonCommercial-NoDerivatives 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 https://creativecommons.org/licenses/by-nc-nd/4.0/
主題
言語 en
主題Scheme Other
主題 choline acetyl transferase (ChAT)
言語 en
主題Scheme Other
主題 glutamic acid decarboxylase (GAD)
言語 en
主題Scheme Other
主題 gephyrin
言語 en
主題Scheme Other
主題 hypoglossal nucleus
言語 en
主題Scheme Other
主題 potassium chloride co-transporter 2 (KCC2)
言語 en
主題Scheme Other
主題 vesicular GABA transporter (VGAT)
内容記述
内容記述タイプ Other
内容記述 In the adult central nervous system (CNS), GABA and glycine (Gly) are predominant inhibitory neurotransmitters, negatively regulating glutamatergic transmission. In the immature CNS, on the other hand, they act as trophic factors, mediating morphogenesis. In the present study, to investigate their involvement in axonal regeneration, we morphologically examined changes in their signaling in mouse hypoglossal nuclei during degeneration and regeneration of hypoglossal nerves. We found that (1) expression and localization of presynaptic elements were not changed, (2) localization of gephyrin, which anchors GABA and Gly receptors, was spread on the surface of motor neuron cell bodies and dendrites, (3) KCC2-expression markedly decreased, (4) choline acetyltransferase, which mediates acetylcholine-synthesis, immediately disappeared from the motor neurons, and (5) the synaptic cleft of both excitatory and inhibitory synapses became irregularly wider, in the hypoglossal nuclei of the sutured side after the operation. These changes gradually normalized during regeneration. These results suggested that synthesis of acetylcholine may be stopped in the motor neuron after axotomy. GABA/Gly may be normally released from presynaptic terminals, be spilled over the original synaptic cleft, be diffused into the neighboring space, bind to extrasynaptically localized receptors, and mediate depolarization of the membrane potential of motor neurons during degeneration and regeneration. Furthermore, it was suggested that GABA/Gly signaling in postsynaptic motor neurons went back to being immature after axotomy, and may play an important role in axonal regeneration.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
識別子
識別子 http://hdl.handle.net/20.500.12000/46546
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.brainres.2012.01.048
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.brainres.2012.01.048
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0006-8993
収録物名
言語 en
収録物名 Brain Research
書誌情報
巻 1446, p. 22-33
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