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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 26巻3・4号
  1. 部局別インデックス
  2. その他

[原著]Heat Stress Promotes the Degradation of p53 and p300/CBP-associated Factor in Murine Embryonic Fibroblasts

http://hdl.handle.net/20.500.12000/0002015565
http://hdl.handle.net/20.500.12000/0002015565
95d7e264-e30f-4eab-baf5-de41bb365c10
名前 / ファイル ライセンス アクション
v26p113.pdf v26p113.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-02-23
タイトル
タイトル [原著]Heat Stress Promotes the Degradation of p53 and p300/CBP-associated Factor in Murine Embryonic Fibroblasts
言語 ja
作成者 Tanaka, Yasuharu

× Tanaka, Yasuharu

en Tanaka, Yasuharu

Morisugi, Toshiaki

× Morisugi, Toshiaki

en Morisugi, Toshiaki

Hironaka, Asako

× Hironaka, Asako

en Hironaka, Asako

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 heat stress
言語 en
主題Scheme Other
主題 heat shock
言語 en
主題Scheme Other
主題 PCAF
言語 en
主題Scheme Other
主題 P53
言語 en
主題Scheme Other
主題 P300
言語 en
主題Scheme Other
主題 Hsp70
言語 en
主題Scheme Other
主題 CBP
内容記述
内容記述タイプ Other
内容記述 Heat stress, like genotoxic- and oxidative-stresses, has been reported to induce nuclear accumulation of p53 and its activation. However, exposure of mouse embryonic fibroblasts to elevated temperature caused insolubilization of nuclear P53 together with its co-activator, P300/CBP-associated factor (PCAF). The insolublized proteins were translocated to the perinuclear region by CRMl-dependent export system, Which was inhibited by leptomycin B. On the other hand, other co-activators, CBP and p300 remained soluble in nucleus. The insolubilization of the two proteins also occurred in other cellines, when the cells were heat-exposed. After the heat stress, the insolublized p53 and PCAF in the cells were degraded by proteasome, which was inhibited by pretreatment of the cells with MG-132. During the degradation, Hsp70-expression was initiated and subsequently newly synthesized p53 and PCAF reappeared as soluble forms in nucleus. These results indicate that nuclear p53 and PCAF transiently disappearpr prior the induction of Hsp70-expression in response to heat stress. Conversely, genotoxic-and oxidative-stress induced neither the loss of these two proteins nor Hsp70-expression.Since p53 functions as a proapoptotic factor and a repressor of Hsp70-expression, the transient disappearance of nuclear p53 and PCAF may partly contribute to the cell survival through the enhancement of Hsp70-expression.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346-888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 26, 号 3・4, p. 113-123
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