{"created":"2022-02-22T03:01:10.788527+00:00","id":2015583,"links":{},"metadata":{"_buckets":{"deposit":"02e19a8a-e79e-47cd-8843-e806f6ce1a24"},"_deposit":{"id":"2015583","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2015583"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02015583","sets":["1642838163960:1642838198944:1642838199408:1642838225283","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"［原著］Cholecystokinin was involved in the development of leptin resistance in OLETF rats","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Motomura, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sunagawa, Masanori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamura, Mariko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kosugi, Tadayoshi","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"cholecystokinin"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"ghrelin"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"leptin"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"OLETF rat"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"obesity"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"leptin resistance"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"To investigate whether a feeding action of ghrelin and an antiobese action of leptin are modified by cholecystokinin (CCK), body weight, food intake, and plasma concentrations of CCK, active ghrelin, desacyl ghrelin and leptin were measured in 7 and 38 weeks old of Otsuka Long-Evans Tokushima Fatty (OLETF) rats which lack CCK1 receptor. Long-Evans Tokushima Otsuka (LETO) rats were used as normal counterpart. The mean body weight, the amount of food intake, active ghrelin and leptin were significantly increased, whereas CCK was significantly decreased in OLETF rats as compared to that in LETO rats at 7 and 38 weeks old. Multiple linear regression analysis revealed that active ghrelin and leptin were significant determinants for prediction of food intake in OLETF rats and that leptin was a significant determinant for body weight in LETO rats. Leptin resistance index (LRI) was calculated by a following equation; LRI = body weight x plasma leptin. The index was negatively correlated with concentration of CCK.Thus, the decreased plasma CCK in OLETF rats may associate with leptin resistance and increase body weight.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346-888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3・4","bibliographicPageEnd":"114","bibliographicPageStart":"105","bibliographicVolumeNumber":"27"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v27p105.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2015583/files/v27p105.pdf"},"version_id":"99ce7dc0-0594-4a2f-b6e6-e610fb8e7517"}]},"item_title":"［原著］Cholecystokinin was involved in the development of leptin resistance in OLETF rats","item_type_id":"15","owner":"1","path":["1642838225283","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-02-23"},"publish_date":"2010-02-23","publish_status":"0","recid":"2015583","relation_version_is_last":true,"title":["［原著］Cholecystokinin was involved in the development of leptin resistance in OLETF rats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:40:36.585320+00:00"}