{"created":"2022-02-22T03:01:30.049364+00:00","id":2015594,"links":{},"metadata":{"_buckets":{"deposit":"dd384f8e-ad79-43fa-a707-20a46eb5180e"},"_deposit":{"id":"2015594","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2015594"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02015594","sets":["1642838163960:1642838198944:1642838199408:1642838223333","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"［総説］The Relationship between Physicochemical Properties of Bound Thrombin and Action Mode of Antithrombin Agent on Bound Thrombin","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakamura, Mariko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sunagawa, Masanori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshioka, Miwa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tengan, Hiroatsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takara, Shigeru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamura, Kazunao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kimura, Yasutaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Motomura, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tamaki, Minao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Uehara, Ken","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kinjoh, Kiyohiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kosugi, Tadayoshi","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"bound thrombin"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"thrombolytic therapy"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"coronary intervention"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"anticoagulant agents"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"structure and function relationship"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Procoagulant activity was known to increase after thrombolytic therapy. It was thought that the enhancement of procoagulant activity was dependent upon the new generation and development of novel kinds of thrombin after thrombolytic therapy. Such thrombin was also produced by percutaneous transluminal coronary angioplasty (PTCA) and percutaneous transluminal coronary reperfusion (PTCR) , resulting in unexpected rethrombosis and vascular restenosis. That is, thrombin appeared again in the circulating blood after thrombolysis or mechanical destruction of the previously formed thrombus. Such the newly generated thrombin was termed postclotting thrombin (bound thrombin). The postclotting thrombins were divided into three classes: native, intact, and bound thrombin. It was emphasized in this review that the bound thrombin generated during the formation of fibrin or thrombus has the clotting activity like a native thrombm. The reliable control of the bound thrombin using synthetic antithrombin agents led the  clinical doctors to reasonable haemostasis, tissue repair and regeneration, and prevention from atherosclerotic change of blood vessel","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346-888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3・4","bibliographicPageEnd":"93","bibliographicPageStart":"85","bibliographicVolumeNumber":"25"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v25p85.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2015594/files/v25p85.pdf"},"version_id":"4ed0c9f9-4122-4b29-9259-e54473cba0f3"}]},"item_title":"［総説］The Relationship between Physicochemical Properties of Bound Thrombin and Action Mode of Antithrombin Agent on Bound Thrombin","item_type_id":"15","owner":"1","path":["1642838223333","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-02-23"},"publish_date":"2010-02-23","publish_status":"0","recid":"2015594","relation_version_is_last":true,"title":["［総説］The Relationship between Physicochemical Properties of Bound Thrombin and Action Mode of Antithrombin Agent on Bound Thrombin"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:40:48.173245+00:00"}