@article{oai:u-ryukyu.repo.nii.ac.jp:02015610,
 author = {Kuang, Hai and Sunakawa, Hajime and Arasaki, Akira and Arakaki, Keiichi and Nakasone, Toshiyuki and Ueda, Gosei and Gibo, Masaki},
 issue = {3・4},
 journal = {琉球医学会誌 = Ryukyu Medical Journal},
 month = {},
 note = {In this retrospective study, we evaluated the effect of carboplatin (CBDCA) selective intra-arterial infusion chemotherapy with concurrent radiotherapy (SIACR) on cervical lymph node metastasis in patients with squamous cell carcinoma in the oral region, and determined the factors related to this effect. Twenty seven patients were enrolled with biopsy-proven squamous cell carcinoma of the oral region. They received CBDCA SIACR for cervical lymph node metastasis and underwent neck dissection. For all patients, 38 metastatic lymph nodes were diagnosed using a number of criteria. The short-axis diameters of lymph nodes were measured on CT images before and after SIACR. All metastatic lymph nodes were histologically classified into complete, good, or poor responses according to their histological features. Level I metastatic lymph nodes were classified as proximal or distal according to the position of the tip of the microcatheter in the feeding artery. In 9 of 27 patients, computed tomography angiography (CTA) was performed to evaluate the vascularity and extent of the primary tumor and metastatic lymph nodes. The reduction percentage of lymph node short-axis diameters was 0%-58.3% with a mean of 26%. Complete response nodes ($36%\pm12%$) showed a significant reduction in short-axis diameters compared with good ($24%\pm15%$) and poor ($27%\pm11%$) response nodes (P<0.05). In the proximal group, 0, 5(63%) and 3 (37%) lymph nodes exhibited complete, good and poor responses. In the distal group, 4 (44%), 5 (56%) and 0 lymph nodes exhibited complete, good and poor responses. The difference between the proximal and distal groups' histological response was statistically significant ( P<0.05). No lymph nodes identified by CTA exhibited a poor response. A correlation between reduction in short-axis diameters of lymph nodes and histological responses was demonstrated in which reduction rates increased with histological response. Findings indicated that histological response was greater for patients in whom the tip of the microcatheter was placed distal to the branching site of the ascending palatine artery. The group with confirmed contrast medium transport to the lymph node metastasis by CT angiography showed a better therapeutic effect, highlighting the importance of confirmation of drug transport by CT angiography., 論文},
 pages = {127--136},
 title = {［原著］Carboplatin Selective Intra arterial Infusion Chemotherapy with Concurrent Radiotherapy on Cervical Lymph Node Metastasis in Squamous Cell Carcinoma in the Oral Region},
 volume = {24},
 year = {2005}
}