{"created":"2022-02-22T03:02:20.574659+00:00","id":2015623,"links":{},"metadata":{"_buckets":{"deposit":"aa9c2301-a1c0-4fcd-8d62-f680cb974d2d"},"_deposit":{"id":"2015623","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2015623"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02015623","sets":["1642838163960:1642838198944:1642838199408:1642838225771","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"［総説］HTLV-1関連脊髄症の病態と病因 : 宿主因子・ウイルス因子の相互作用と発症への関与","subitem_1551255648112":"ja"},{"subitem_1551255647225":"Clinical characteristics and pathogenesis of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"斎藤, 峰輝","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"Saito, Mineki","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"HTLV-1"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"HAM/TSP"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"HLA"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"immune response"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic progressive myelopathy characterized by spastic paraparesis and sphincter dysfunction observed in a minority of HTLV-1 infected individuals. Previously studies indicated that HTLV-1 Tax subtype, several HLA and non-HLA genes are closely associated with the development of HAM/TSP. Two HAM/TSP associated alleles, HLA-A^*02 and HLA-DRB1^*0101 can recognize immunodominant HTLV-1 epitopes, and some HAM/TSP associated non-HLA genes are trans-activated by HTLV-1 Tax protein. Namely, complex virus-host interactions play an important role in determining the risk of HAM/TSP.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"jpn"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346-888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1・2","bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographicVolumeNumber":"28"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v28p1.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2015623/files/v28p1.pdf"},"version_id":"70f2904e-c888-4892-bb2f-fb36fdf60e18"}]},"item_title":"［総説］HTLV-1関連脊髄症の病態と病因 : 宿主因子・ウイルス因子の相互作用と発症への関与","item_type_id":"15","owner":"1","path":["1642838225771","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-04-28"},"publish_date":"2010-04-28","publish_status":"0","recid":"2015623","relation_version_is_last":true,"title":["［総説］HTLV-1関連脊髄症の病態と病因 : 宿主因子・ウイルス因子の相互作用と発症への関与"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:41:20.250866+00:00"}