{"created":"2022-02-22T03:12:57.578802+00:00","id":2015699,"links":{},"metadata":{"_buckets":{"deposit":"29790306-2b4b-4dcb-a631-a1ab56216b26"},"_deposit":{"id":"2015699","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2015699"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02015699","sets":["1642838163960:1642838198944:1642838233003:1642838234333","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[原著］ハブ毒による中毒死に関する研究(第2報): 成犬静脈内-ブ毒投与後の病態生理学的研究","subitem_1551255648112":"ja"},{"subitem_1551255647225":"Pathophysiological Study of Habu-bite Death : Study of intravenous envenomation in the dog","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井上, 治","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"Inoue, Osamu","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Habu-venom"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Intravenous-envenomation"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Habu-bite death"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Pathophysiology"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"In order to eliminate local factors, such as edema in intramuscular envenomation previously reported, intravenous envenomation of 1.0 mg/kg of Habu-venom was performed in this experiment. As a result of intramuscular envenomation, respiratory compensation was observed secondary to lactic acidosis or massive hemolysis, but hyperkaliemia might have been masked by hyperventilation. So in this experiment respiration was controlled. The course of recovery was also observed after 0.5 mg/kg of Habu-venom envenomation. Cardiovascular monitering of E.C.G, arterial pressure and central venous pressure were recorded on polygraph system. Arterial blood gas analysis, lactic acid, serum potassium, serum hemoglobin and coagulation tests etc. were analyzed every 30 minutes throughout the experiment. In intravenous envenomation, systemic toxic effect was more than 10 times stronger than in intramuscular envenomation. Especially massive hemolysis with hemoglobinuria and disseminated intravascular coagulation were observed in adition to progressive hypotension with lactic acidosis. In spite of massive hemolysis, hyperkaliemia was not present even in controlled respiration. However hyperkaliemia observed in terminal stage was thought to be secondary to advanced acidosis. During the course of recovery, there showed sudden drop of arterial blood pressure after envenomation with moderate hemolysis, lactic acidosis and D.I.C. like coagulopathy, however the recovery was complete in two to three hours. Biphasic depression of arterial blood pressure was similar to that of Endotoxin shock , so the initial drop of arterial blood pressure was suggestive of rapid pooling in vascular beds. Irreversible shock as a result of continous hypotension, cardiac depression and lactic acidosis by Habu-venom was probably the cause of death in dog.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球大学医学部"},{"subitem_1522300295150":"en","subitem_1522300316516":"Faculty of Medicine, University of the Ryukyus"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"jpn"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10027430"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球大学医学会雑誌 : 医学部紀要 = Ryukyu medical journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1983","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"179","bibliographicPageStart":"167","bibliographicVolumeNumber":"6"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v6p167.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2015699/files/v6p167.pdf"},"version_id":"964ecb2e-eee3-4c4a-9865-d3da9b737fdf"}]},"item_title":"[原著］ハブ毒による中毒死に関する研究(第2報): 成犬静脈内-ブ毒投与後の病態生理学的研究","item_type_id":"15","owner":"1","path":["1642838234333","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-06-30"},"publish_date":"2010-06-30","publish_status":"0","recid":"2015699","relation_version_is_last":true,"title":["[原著］ハブ毒による中毒死に関する研究(第2報): 成犬静脈内-ブ毒投与後の病態生理学的研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:42:51.889603+00:00"}