@article{oai:u-ryukyu.repo.nii.ac.jp:02015742,
 author = {新垣, 晃 and 茨木, 邦夫 and 嘉陽, 宗俊 and 武内, 正典 and 外間, 浩 and 石川, 裕二 and 田中, 重徳},
 issue = {1},
 journal = {琉球大学医学会雑誌 : 医学部紀要 = Ryukyu medical journal},
 month = {},
 note = {Relationship between newly formed endplate and original endplate in the denervated muscle after direct nerve implantation was studied in the rat. Wistar rats were divided into three groups, in group 1 (Denervation group), the common peroneal nerve was resected at the fibular head, in group 2 (Nerve repair group), the common peroneal nerve was severed at the fibular head and nerve repair was performed immediately using standard microsurgical technique, in group 3 (Neurotization group), tibial nerve was cut at the ankle level, and then the funiculus of the proximal stump of tibial nerve was splitted and implanted into the dista1 1/4 to 1/5 part of the muscle in the area there is no endplate after denervation of the anterior tibial muscle. Wet weight of the anterior tibial muscle and strength of the muscle tonically contracted by electric stimulation were measured. Histological change of the endplate and muscle was examined using acetylcholine receptor (Ach-R) stain and acetylcholine esterase (Ach-E) stain. In group 2 and 3, wet weight of the muscle and tonic contraction strength by the electric stimulation were increased beyond four weeks after the operation. Histologically, in group 1 , the original endplate was elongated following muscle atrophy without changing the principal features of the endplate. In group 2, the original endplates were almost unchanged even at 20 weeks after the operation. In group 3, the original endplates were almost normal in shape. On the other hand, ectopic endplates were found out at the neurotized sites at where there had been no original endplates. The new endplate was large and un formed and quite different from the original endplate in its shape and size. In conclusion, the mechanism of reinnervation of the denervated muscle by the direct nerve implantation was completely different from that by the nerve repair: The new endplate was formed by neurotization, whereas the original endplate was reinnervated by nerve repair., 論文},
 pages = {27--33},
 title = {[原著］ラットを用いたNeurotizationに関する実験的研究 : 第1報},
 volume = {10},
 year = {1987}
}