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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球大学医学会雑誌
  4. 9巻3-4号
  1. 部局別インデックス
  2. その他

[症例報告]皮膚 Histiocytosis X の1症例

http://hdl.handle.net/20.500.12000/0002015767
http://hdl.handle.net/20.500.12000/0002015767
457c3c23-ef37-42cc-b981-68b50b0091fc
名前 / ファイル ライセンス アクション
v9p202.pdf v9p202.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-06-30
タイトル
タイトル [症例報告]皮膚 Histiocytosis X の1症例
言語 ja
作成者 仲間, 健

× 仲間, 健

ja 仲間, 健

新垣, 京子

× 新垣, 京子

ja 新垣, 京子

伊藤, 悦男

× 伊藤, 悦男

ja 伊藤, 悦男

野原, 雄介

× 野原, 雄介

ja 野原, 雄介

Miyashiro, JamesS

× Miyashiro, JamesS

en Miyashiro, JamesS

Nakama, Tekeshi

× Nakama, Tekeshi

en Nakama, Tekeshi

Arakaki, Kyoko

× Arakaki, Kyoko

en Arakaki, Kyoko

Ito, Etsuo

× Ito, Etsuo

en Ito, Etsuo

Nohara, Yusuke

× Nohara, Yusuke

en Nohara, Yusuke

Miyashiro, JamesS

× Miyashiro, JamesS

en Miyashiro, JamesS

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 Skin
言語 en
主題Scheme Other
主題 histiocytosis X
内容記述
内容記述タイプ Other
内容記述 A 64-Year-old woman came to the hospital for anal pain. Physical examination disclosed an ulcerative lesion at the anus. Laboratory findings on admission were within normal range except for ASLO (+), ALP 21.5U/1, and a erythrocyte sedimentation rate of 37mm/h. X-ray examination of bone and colon did not show any abnormality. Histological examination of the resected specimen showed a band-like, solid proliferation of histiocyte like cells along the ulcer base. These cells were large, rounded cells with abundant, slightly eosinophilic cytoplasm. The nucleus was oval or indented or kidney shaped. The nucleolus was not prominant. Both PAS and sudan III stains were negative. Electron microscopically Birbeck granules were seen in the cytoplasm of the cells. But tonofilaments or melanosomes were not found. In addition, junctional apparatus as desmosome was not observed. Immunohistochemical examination by PAP method of Sternberger revealed a positive for S1OO protein and a negative for lysozyme and $ \alpha $1 anti-trypsin. These results indicate that the histiocyte like cells are Langerhans cells. Langerhans cells have been considered to be a member of the mononuclear phagocytic system, because of the expression of similar immunological markers such as Fc and C3 receptors which are common in both Langerhans cells and cells in the mononoclear phagocytic system. But recent reports suggest some differences between Langerhans cells and cells in the monuclear phagocytic system. Langerhans cells are S1OO protein +, lysozyme -, NCA (nonspecific cross reacting antigen with carcinoembryonic antigen) -, whereas monocytes and macrophages are S1OO protein -, lysozyme +, NCA +. Watanabe. S., et al propose the hypothesis that there are two histiocytic cell lines; one is the monocyte-macrophage system, another is the T-zone histiocyte system. The cells in the T-zone histiocyte system include Langerhans cell and indeterminate cell in the epidermis and interdigitating cell in the lymph node and spleen. The function of the T-zone histiocyte is still unknown. However it is very interesting that the celle of the T-zone histiocyte increase in number, associated with the diseases related to the allergy or immuunological abnormality or with lympho-proliferative disorders as mycosis fungoides.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球大学医学部
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10027430
収録物名
言語 ja
収録物名 琉球大学医学会雑誌 : 医学部紀要 = Ryukyu medical journal
書誌情報
巻 9, 号 3-4, p. 202-208
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