@article{oai:u-ryukyu.repo.nii.ac.jp:02015781,
 author = {佐久田, 治 and 六川, 二郎 and 高良, 英一 and 中田, 宗朝 and 金城, 利彦 and 外間, 朝哲 and Sakuta, Osamu and Mukawa, Jiro and Takara, Eiichi and Nakata, Munetomo and Kinjo, Toshihiko and Hokama, Asanori},
 issue = {3-4},
 journal = {琉球大学医学会雑誌 : 医学部紀要 = Ryukyu medical journal},
 month = {},
 note = {A 36-year-old woman suffered from headache and swelling of the face and limbs. Neurological examination revealed mild weakness and a prolonged relaxation phase of deep tendon reflexes. MRI(T1 weighted images : SE 500/30) showed pituitary enlargement extending to supraseller region. Serum T3 and T4 were low, and TSH was abnormally high. In anterior pituitary hormone assessment test, there was a notable increase in both TSH and prolactin concentrations by the administration of TRH. Thyroid replacement therapy was programmed without surgery, and the pituitary gland was checked by MRI. Within 3 months after the therapy serum T3 and T4 were normalized and TSH level was reduced. The pituitary gland was reduced in size from 17×10×18mm to 7 ×10×10mm measured by MRI. Characteristic MRI findings of our case was a round high intensity mass in the midline of the pituitary region in T1 weighted images(SE 500/30). Only 8 cases of pituitary regression by thyroid replacement therapy were reported in the literature. They were considered to be pituitary hyperplasia, rather than pituitary adenoma, caused by longstanding untreated hypothyroidism. Pituitary hyperplasia with hipothyroidism tend to be mistaken for pituitary adenoma, although endocrinological examination may be ruled it out. The first choice of the treatment for this type of pituitary mass should be thyroid replacement therapy unless the patient has a severe visual disturbance. If there is no regression of pituitary mass, then diagnosis is to be adenoma and surgery should be indicated., 論文},
 pages = {180--184},
 title = {[症例報告]下垂体腫瘤を形成した原発性甲状腺機能低下症の1治験例},
 volume = {10},
 year = {1988}
}