{"created":"2022-02-22T03:16:33.943704+00:00","id":2015821,"links":{},"metadata":{"_buckets":{"deposit":"a13284e4-3256-4c7f-a534-2f89f28686b1"},"_deposit":{"id":"2015821","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2015821"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02015821","sets":["1642838163960:1642838198944:1642838199408:1642838199879","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[原著］The Effects of Ethanol Oral Administration and Toluene Inhalation Exposure on Plasma Free Large Neutral Amino Acids in Wistar Rats","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Dominicus, Dalmas A. R.","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"ethanol"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"toluene"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"neutral amino acids"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"branched chain amino acids"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"aromatic amino acids"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"behavioural changes"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"To investigate the effects of ethanol or tuluene on the large neutral amino acids (LNAA) and plasma ratios tryptophan/LNAA and tyrosine/LNAA, known under physiological conditions to predict the brain concentrations of tryptophan and tyrosine respectively, a study was carried out involving Male Wistar rats divided into alcohol (ethanol) 20 rats, and toluene inhalation 20 rats, for a period of two months. Using t test ethanol oral administration caused consistent and significant increase in plasma branched chain amino acids (BCAA). Ethanol also caused a significant decrease in plasma ratio of tryptophan/LNAA. Toluene showed no effect on the BCAA as well as the plasma ratio of tryptophan/LNAA, but caused a significant increase in plasma ratio of tyrosine/LNAA. Tryptophan is the precusor of cerebral indolylamine 5-hydroxytryptamine (5-HT) , which is believed to be involved in neurotransmission and regulation of mood and possibly also certain other behaviours. Therefore the plasma amino acid characteristics observed in this study may contribute to sustaining or accentuating mood and behavioural changes seen in alcoholics. More research is needed in this area to help in varifying these findings especially in human subjects who are alcoholics or those exposed to toluene.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"33","bibliographicPageStart":"22","bibliographicVolumeNumber":"12"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v12p22.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2015821/files/v12p22.pdf"},"version_id":"57728a29-4127-4e78-acd8-b4a5e281ea6a"}]},"item_title":"[原著］The Effects of Ethanol Oral Administration and Toluene Inhalation Exposure on Plasma Free Large Neutral Amino Acids in Wistar Rats","item_type_id":"15","owner":"1","path":["1642838199879","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2015821","relation_version_is_last":true,"title":["[原著］The Effects of Ethanol Oral Administration and Toluene Inhalation Exposure on Plasma Free Large Neutral Amino Acids in Wistar Rats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:45:08.475071+00:00"}