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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 12巻4号
  1. 部局別インデックス
  2. その他

[原著]N-isopropyl-p-[ ^<123>I ] iodoamphetamineとsingle photon emission computed tomographyによるアルツハイマー型痴呆の局所脳血流測定

http://hdl.handle.net/20.500.12000/0002015825
http://hdl.handle.net/20.500.12000/0002015825
af3845ac-cc40-4ebf-94d9-77ade6c91d95
名前 / ファイル ライセンス アクション
v12p327.pdf v12p327.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]N-isopropyl-p-[ ^<123>I ] iodoamphetamineとsingle photon emission computed tomographyによるアルツハイマー型痴呆の局所脳血流測定
言語 ja
作成者 堀川, 歩

× 堀川, 歩

ja 堀川, 歩

山口, 慶一郎

× 山口, 慶一郎

ja 山口, 慶一郎

山崎, 英樹

× 山崎, 英樹

ja 山崎, 英樹

国吉, 和秀

× 国吉, 和秀

ja 国吉, 和秀

勝山, 直文

× 勝山, 直文

ja 勝山, 直文

目黒, 謙一

× 目黒, 謙一

ja 目黒, 謙一

Horikawa, Ayumi

× Horikawa, Ayumi

en Horikawa, Ayumi

Yamaguchi, Keiichiro

× Yamaguchi, Keiichiro

en Yamaguchi, Keiichiro

Yamazaki, Hideki

× Yamazaki, Hideki

en Yamazaki, Hideki

Kuniyoshi, Kazuhide

× Kuniyoshi, Kazuhide

en Kuniyoshi, Kazuhide

Katsuyama, Naofumi

× Katsuyama, Naofumi

en Katsuyama, Naofumi

Meguro, Ken-ichi

× Meguro, Ken-ichi

en Meguro, Ken-ichi

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 IMP
言語 en
主題Scheme Other
主題 SPECT
言語 en
主題Scheme Other
主題 regional CBF
言語 en
主題Scheme Other
主題 dementia of Alzheimer type
内容記述
内容記述タイプ Other
内容記述 Measurement of regional cerebral blood flow (CBF) was done, using N-isopropyトp-[^<123>I]-iodoamphetamine(IMP)on 24 patients with dementia of Alzheimer type (DAT)and 13 age-matched controls. We used SPECT and arterial blood sampling for quantitative measurement of regional CBF. The same psychiatrist estimated clmical state and dementia ratig. We divided DAT patients into two groups according to the Clinical Dementia Rating(CDR). One was mild and moderate DAT group(12 patients, mean age 81.3), and the other was severe DAT group(12patients, mean age 82.6). Mean CBF of cerebral cortex was 47.3ml/100g/min in the normal control group, 46.0ml/100g/min in the mild and moderate DAT group and 37.2ml/100g/min in the severe DAT group. There was significant difference between normal control group and severe DAT group(p<0.01). No significant difference was seen between mild and moderate DAT group and normal control group. Relative CBFs were calculated as ratios of regional activity to cerebellar activity on SPECT image. Ratios of mean cortical activity to cerebellar activity revealed significant difference between normal control group and severe DAT group(p<0.01). There is no significant difference between mild and moderate DAT group and normal control group. On quantitative measurement method, CBF were globally reduced in all the regions of brain except brain stem in severe DAT group. Relative CBF study revealed CBF reduction in frontal, parietal, temporal and occipital cortex but no CBF reduction in cerebellum, precentral gyrus and deep gray matter in severe DAT group. Relative CBF study underestimated CBF reduction when compared with the quantitative method. The cause for this was reduction of mean CBF of cerebellum in severe DAT group compared with normal control group.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 12, 号 4, p. 327-343
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