{"_buckets": {"deposit": "96e4a377-542b-4c65-b700-6f676eb90294"}, "_deposit": {"id": "2015827", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2015827"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02015827", "sets": ["1642838203782", "1642838412624"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "[原著］Prethymic Nylon Wool-Passed Bone Marrow Cells Can Make Distinction between Self and Non-Self X-Chromosome-Linked Gene Products (Xir Antigens) on the Stimulator Cells, Resulting in Regulation of the Generation of Cytotoxic T Lymphocytes in Mixed Lymphocyte Cultures", "subitem_1551255648112": "ja"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Higa, Moritake", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tanabe, MasaoJ.", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "琉球医学会"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "X-chromosome"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "bone marrow cells"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "self-nonself discrimination"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "cytotoxic T lymphocytes"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "We have previously reported that nylon wool-passed bone marrow cells treated with anti-Thy.1 antibody and complement (Thy.1 NW-BM cells) had helper-like activity which could augment the generation of cytotoxic T lymphocytes (CTL). In this study, we determined the antigens to which these NW-BM cells responded and recognized. When a few responder lymph node (LN) cells and an excess of NW-BM responder cells from BIOBR (H-2^k B10 background) mice were cultured with stimulator spleen cells from either B10D2 (H-2^k, B10 background) or BALB/c (H-2^d, BALB/c background) mice, the number of CTL induced by the stimulation with BALB/c spleen cells was significantly higher than in those from B10D2 mice. When the cells from BALB.K (H-2^k. BALB/c background) mice were used as the responder, the results showed that B10D2 spleen cells were better stimulators than those of BALB/c. These results showed that NW-BM cells responded to the nonself allogeneic background gene products on the stimulator cells, but not to those of self, and that these responder NW-BM cells augmented CTL generation. We genetically analyzed the antigens that NW-BM cells recognized among many products derived from background genes. B10BR NWBM cells were well stimulated by (BALB.KXB10D2) F1 male spleen cells, but not by those of (B10D2×BALB.K) F1 males. On the contrary, BALB.K NW-BM cells were highly stimulated by (B10D2XBALB.K) F1 males, but not by (BALB.KXB10D2) F1 males. These results showed that NW-BM c?lIs had a strict preference for X-chromosome linked gene products (Xir antigens). We also showed that the augmenting ability of NW-BM cells was attributed to the Thy.1 population, and that BALB/c NW-BM cells possessing the H-2^d haplotype also responded preferentialy to nonself Xir antigens, To conclude, NW-BM cells could distinguish between self and non-self Xir antigens, resulting in regulation of the CTL response.", "subitem_description_type": "Other"}, {"subitem_description": "論文", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "琉球医学会"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "Ryukyu Medical Association"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1346888X"}, {"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0289-1530"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN10369445"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "琉球医学会誌 = Ryukyu Medical Journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "1", "bibliographicPageEnd": "41", "bibliographicPageStart": "33", "bibliographicVolumeNumber": "14"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "NA", "subitem_1600292170262": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "v14p33.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2015827/files/v14p33.pdf"}, "version_id": "df63ea16-4589-4fa2-a14f-c5392cc56598"}]}, "item_title": "[原著］Prethymic Nylon Wool-Passed Bone Marrow Cells Can Make Distinction between Self and Non-Self X-Chromosome-Linked Gene Products (Xir Antigens) on the Stimulator Cells, Resulting in Regulation of the Generation of Cytotoxic T Lymphocytes in Mixed Lymphocyte Cultures", "item_type_id": "15", "owner": "1", "path": ["1642838203782", "1642838412624"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002015827", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-07-02"}, "publish_date": "2010-07-02", "publish_status": "0", "recid": "2015827", "relation": {}, "relation_version_is_last": true, "title": ["[原著］Prethymic Nylon Wool-Passed Bone Marrow Cells Can Make Distinction between Self and Non-Self X-Chromosome-Linked Gene Products (Xir Antigens) on the Stimulator Cells, Resulting in Regulation of the Generation of Cytotoxic T Lymphocytes in Mixed Lymphocyte Cultures"], "weko_shared_id": -1}