{"created":"2022-02-22T03:16:44.152812+00:00","id":2015827,"links":{},"metadata":{"_buckets":{"deposit":"96e4a377-542b-4c65-b700-6f676eb90294"},"_deposit":{"id":"2015827","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2015827"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02015827","sets":["1642838163960:1642838198944:1642838199408:1642838203782","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[原著］Prethymic Nylon Wool-Passed Bone Marrow Cells Can Make Distinction between Self and Non-Self X-Chromosome-Linked Gene Products (Xir Antigens) on the Stimulator Cells, Resulting in Regulation of the Generation of Cytotoxic T Lymphocytes in Mixed Lymphocyte Cultures","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Higa, Moritake","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanabe, MasaoJ.","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"X-chromosome"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"bone marrow cells"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"self-nonself discrimination"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"cytotoxic T lymphocytes"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"We have previously reported that nylon wool-passed bone marrow cells treated with anti-Thy.1 antibody and complement (Thy.1 NW-BM cells) had helper-like activity which could augment the generation of cytotoxic T lymphocytes (CTL). In this study, we determined the antigens to which these NW-BM cells responded and recognized. When a few responder lymph node (LN) cells and an excess of NW-BM responder cells from BIOBR (H-2^k B10 background) mice were cultured with stimulator spleen cells from either B10D2 (H-2^k, B10 background) or BALB/c (H-2^d, BALB/c background) mice, the number of CTL induced by the stimulation with BALB/c spleen cells was significantly higher than in those from B10D2 mice. When the cells from BALB.K (H-2^k. BALB/c background) mice were used as the responder, the results showed that B10D2 spleen cells were better stimulators than those of BALB/c. These results showed that NW-BM cells responded to the nonself allogeneic background gene products on the stimulator cells, but not to those of self, and that these responder NW-BM cells augmented CTL generation. We genetically analyzed the antigens that NW-BM cells recognized among many products derived from background genes. B10BR NWBM cells were well stimulated by (BALB.KXB10D2) F1 male spleen cells, but not by those of (B10D2×BALB.K) F1 males. On the contrary, BALB.K NW-BM cells were highly stimulated by (B10D2XBALB.K) F1 males, but not by (BALB.KXB10D2) F1 males. These results showed that NW-BM c?lIs had a strict preference for X-chromosome linked gene products (Xir antigens). We also showed that the augmenting ability of NW-BM cells was attributed to the Thy.1 population, and that BALB/c NW-BM cells possessing the H-2^d haplotype also responded preferentialy to nonself Xir antigens, To conclude, NW-BM cells could distinguish between self and non-self Xir antigens, resulting in regulation of the CTL response.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueNumber":"1","bibliographicPageEnd":"41","bibliographicPageStart":"33","bibliographicVolumeNumber":"14"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"NA","subitem_1600292170262":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v14p33.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2015827/files/v14p33.pdf"},"version_id":"df63ea16-4589-4fa2-a14f-c5392cc56598"}]},"item_title":"[原著］Prethymic Nylon Wool-Passed Bone Marrow Cells Can Make Distinction between Self and Non-Self X-Chromosome-Linked Gene Products (Xir Antigens) on the Stimulator Cells, Resulting in Regulation of the Generation of Cytotoxic T Lymphocytes in Mixed Lymphocyte Cultures","item_type_id":"15","owner":"1","path":["1642838203782","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2015827","relation_version_is_last":true,"title":["[原著］Prethymic Nylon Wool-Passed Bone Marrow Cells Can Make Distinction between Self and Non-Self X-Chromosome-Linked Gene Products (Xir Antigens) on the Stimulator Cells, Resulting in Regulation of the Generation of Cytotoxic T Lymphocytes in Mixed Lymphocyte Cultures"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:45:14.859457+00:00"}