@article{oai:u-ryukyu.repo.nii.ac.jp:02015849, author = {Tomita, Shuji and Muto, Yoshihiro and Kusano, Toshiomi and Deguchi, Shigeru and Toda, Takayoshi}, issue = {4}, journal = {琉球医学会誌 = Ryukyu Medical Journal}, month = {}, note = {A case of a huge carcinoid tumor of the gallbladder in a 68-year-old Japanese woman is reported herein. The patient presented with a huge mass in the right upper quadrant of the abdomen without a carcinoid syndrome. Diagnostic modaliLies demonstrated a huge tumor suggesting some malignant tumors of the gallbladder. Right hepatectomy with cholecystectomy and regional nodal dissection was carried out. The tumor together with the right hepatic lobe weighed 3,018 gm and the tumor itself measured 23× 18× 16 cm in size. Upon bisection, it was solid and well circumscribed, containing gallstones without any spread to the liver and regional lymph nodes. Microscopically, the tumor was composed of solid or trabecular nests with atypical polygonal cells which were argyrophil positive, expressed by CEA and chromogranin A, but not by NSE. They possessed several dense core neurosecretory granules on electron microscopic examination. Based on these morphological data, this carcinoid tumor was thought to be categorized as an endocrine cell carcinoma of a poorly differentiated carcinoid. The patient expired eight months after surgery with massive hepatic metastases. This case might be the largest carcinoid tumor from this location reported in literature., 論文}, pages = {361--367}, title = {[症例報告]Huge Carcinoid Tumor of the Gallbladder : A Case Report}, volume = {13}, year = {1993} }