{"created":"2022-02-22T03:30:19.243551+00:00","id":2015854,"links":{},"metadata":{"_buckets":{"deposit":"8d1bc1d7-39f5-490e-8263-30560daf786a"},"_deposit":{"id":"2015854","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2015854"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02015854","sets":["1642838163960:1642838198944:1642838199408:1642838200917","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"[原著］Increased Susceptibility of B-cells in Protein-Calorie Malnutrition to Long Term Low Dose Streptozotocin and Its Effect on Re-feeding","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Islam, Mohammad Rashidul","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Murakami, Keiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"WakugamiTamio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mimura, Goro","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"琉球医学会","subitem_rights_language":"ja"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Streptozotocin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nutrition disorders","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Islet of Langerhans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Protein-calorie malnutrition","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The susceptibility of pancreatic B-cells of protein-calorie malnourished(PCM) rats to long term low  dose streptozotocin(STZ) and the effect of this low dose STZ on refeeding were studied. Male weanling  Wistar rats were fed either by 20%(30=normal) or 4%(30=PCM) protein diet. Twenty of each two  groups were treated with STZ(5mg/kg/day i.m.) and the rest with buffer for one month. Ten of each  STZ treated normal and PCM rats were re-fed with 20% protein diet for another one month called  as RF-normal and RF-PCM respectively. Wet wt. of liver and pancreas, plasma lipids and insulin  were measured. IPGTT, morphometric and histologic study of islets were done. PCM+STZ showed  significantly high fasting plasma glucose (FPG) $175.9 \\pm 46.6$ compared to $88.8 \\pm 12.9$mg/dl ($mean \\pm SD$) in normal+STZ rats. Both STZ and vehicle treated PCM rats showed impaired IPGTT with peak plasma  glucose $663.4 \\pm 87.8$ and $465.8 \\pm 97.2$mg/dl ($mean \\pm SD$) respectively. Areas under curves in case of IPGTT  were significantly high in PCM with and without STZ than in normal with and without S12. These  were also significantly high in normal and PCM with STZ, compared to normal and PCM without  STZ. No./field and size of islet, % of B-cell area/islet and insulin levels were significantly reduced  (pくO.01 vs. normal) in both STZ and vehicle treated PCM rats. Degree of reduction was more prominent  in PCM+STZ. FPG remained high with $221.0 \\pm 98.8$mg/dl despite some nutritional recovery in RF-PCM  rats. Areas under curves in case of IPGTT were significantly high in RF-PCM than RF-normal in  both before and after refeeding. The area under curve reduced significantly in RF-normal after refeeding  but it was unchanged in RF-PCM rats. RF-PCM rats also showed significant reduction in  morphometry and insulin level (p<0.01 vs. RF-nomal) and degree of reduction was more in RE-PCM  after re-feeding. Histologic findings showed close correlationship with morphometry. We concluded  that B-cel1s of morphologinIly altered islets of PCM rats were more susceptible to STZ and the effect  of STZ was persistent after refeeding. These suggest the possibility of increased susceptibility of  pancreatic B-cells to other B-cytotoxic influences as STZ in PCM in childhood and exposure to these  agents might produce an irreversible change to the endocrine pancreas.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"琉球医学会","subitem_publisher_language":"ja"},{"subitem_publisher":"Ryukyu Medical Association","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1346888X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"0289-1530","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN10369445","subitem_source_identifier_type":"NCID"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_source_title":"琉球医学会誌 = Ryukyu Medical Journal","subitem_source_title_language":"ja"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"218","bibliographicPageStart":"206","bibliographicVolumeNumber":"12"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v12p206.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2015854/files/v12p206.pdf"},"version_id":"583b5c1e-9003-4cb5-a9c3-5a49a8460d11"}]},"item_title":"[原著］Increased Susceptibility of B-cells in Protein-Calorie Malnutrition to Long Term Low Dose Streptozotocin and Its Effect on Re-feeding","item_type_id":"15","owner":"1","path":["1642838200917","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2015854","relation_version_is_last":true,"title":["[原著］Increased Susceptibility of B-cells in Protein-Calorie Malnutrition to Long Term Low Dose Streptozotocin and Its Effect on Re-feeding"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:45:45.077387+00:00"}