@article{oai:u-ryukyu.repo.nii.ac.jp:02015855,
 author = {砂川, 長彦 and 戸沢, 雅彦 and 瀧下, 修一 and 柊山, 幸志郎 and Sunagawa, Osahiko and Tozawa, Masahiko and Takishita, Shuichi and Fukiyama, Koshiro},
 issue = {1},
 journal = {琉球医学会誌 = Ryukyu Medical Journal},
 month = {},
 note = {To clarify whether or not sodium restriction has an influence on central mechanisms of hypertension, we investigated characteristics of $ \alpha $1-and $ \alpha $2-adrenoceptors in central nervous system in SHR fed on low sodium diet. SHR and wistar-Kyoto rats (WKY) were divided into 2 groups and fed on either low sodium diet containing 0.05% sodium or normal sodium diet containing 0.4% sodium from 3 weeks of age. The experiments were performed at 6,8 and 20 weeks of age. The rat brains were divided into cortex, hypothalamus and lower brainstem. Plasma membranes were prepared, and radioligand binding studies were performed using [^3H]prazosin for $ \alpha $1-adrenoceptors and [^3H]rauwolscine for $ \alpha $2-adrenoceptors. There was no difference in body wight between low and normal sodium diet, while WKY remained normotensive. The Bmax of $ \alpha $1-adrenoceptor was increased significantly in the cortex and hypothalamus in SHR fed on normal sodium diet at 20 weeks of age and in the cortex, hypothalamus, and lower brainstem in SHR fed on low sodium diet at 8 weeks of age compared with those of respective WKY. There was no consistent change in Kd of $ \alpha $1-adrenoceptor in SHR compared with WKY. The Bmax of $ \alpha $2-adrenoceptor was increased in the cortex and hypothalamus in SHR fed on normal sodium diet at 8 weeks of age compared with WKY on the same diet and at the same age, while no increase in SHR fed on low sodium diet was observed. The Kd of $ \alpha $2-adrenoceptor was not changed consistently in SHR on either sodium diet. These results suggest that an increase in $ \alpha $1-adrenoceptor Bmax in hypothalamus might be related genetically to the initiation of hypertension in SHR., 論文},
 pages = {62--73},
 title = {[原著］低食塩飼育による高血圧自然発症 : ラットの中枢神経$ \alpha $_1及び$ \alpha $_2受容体の変化},
 volume = {12},
 year = {1991}
}