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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 12巻4号
  1. 部局別インデックス
  2. その他

[原著]拡大肝切除時に網内系賦括剤の投与や脾摘の意義に関する実験的研究

http://hdl.handle.net/20.500.12000/0002015866
http://hdl.handle.net/20.500.12000/0002015866
226f70a6-484c-452c-bd5a-f3f8f70f3da7
名前 / ファイル ライセンス アクション
v12p317.pdf v12p317.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]拡大肝切除時に網内系賦括剤の投与や脾摘の意義に関する実験的研究
言語 ja
タイトル
タイトル Experimental study of implication of activation of reticuloendothelial function by injection of OK-432 and splenectomy on 93% hepatectomy in rats
言語 en
作成者 宮良, 球一郎

× 宮良, 球一郎

ja 宮良, 球一郎

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Miyara, Kyuichirou

× Miyara, Kyuichirou

en Miyara, Kyuichirou

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 93%hepatectomy
主題
言語 en
主題Scheme Other
主題 OK-432
主題
言語 en
主題Scheme Other
主題 splenectomy
主題
言語 en
主題Scheme Other
主題 reticuloendotherial function
内容記述
内容記述タイプ Other
内容記述 The purpose of this study is to evaluate the influence of increased activity of reticuloendothelial function by OK-432 and splenectomy on hepatic regeneration following 93% hepatectomy in rats. Wister-maie rats weighting 240g to 320g were randomly allocated to 4 experimental groups and subjected to the following regimen :(1) A group; 93% hepatectomy alone,(2) B group; 93% hepatectomy+splenectomy, (3) C group; OK-432+93% hepatectomy, (4) D group; OK-432+93% hepatectomy+splenectomy. Survival rates after hepatectomy, initial, 24hour, 48hour, serum endotoxin, S- GOT, S-GPT in each group were determined. The long-term (180 days following hepatectomy) survival rates was 45.5% in A group, 13.6% in B group, 6.4% in Cgroup and 6.3% in D group, respectively and A group survival was statistically significant better compared with other three groups. Serum endotoxin titers prior to hepatectomy were significantly lower (0.926 pg/ml) in OK-432 treated groups than in non-treated groups (3.3pg/ml). 24hours after hepatectomy, A group showed marked increase titers of endotoxin with statistical significance compared with other three groups. S-GOT and S-GPT markedly elevated 24hours after hepatectomy, but returned to the normal values 48hours after hepatectomy. These results might suggest that in 93% experimental hepatectomy in rats, activation of reticuloendotherial function could be harmful in liver regeneration after hepatectomy, and lower survival rate from the long-term survival points, therefore, another unknown mechanism might play an important role in liver damage after hepatectomy.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
出版者
言語 en
出版者 Ryukyu Medical Association
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 12, 号 4, p. 317-326, 発行日 1992
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