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[原著］拡大肝切除時に網内系賦括剤の投与や脾摘の意義に関する実験的研究
http://hdl.handle.net/20.500.12000/0002015866
http://hdl.handle.net/20.500.12000/0002015866226f70a6-484c-452c-bd5a-f3f8f70f3da7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v12p317.pdf
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| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2010-07-02 | |||||||||
| タイトル | ||||||||||
| タイトル | [原著］拡大肝切除時に網内系賦括剤の投与や脾摘の意義に関する実験的研究 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Experimental study of implication of activation of reticuloendothelial function by injection of OK-432 and splenectomy on 93% hepatectomy in rats | |||||||||
| 言語 | en | |||||||||
| 作成者 |
宮良, 球一郎
× 宮良, 球一郎
× Miyara, Kyuichirou
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 言語 | ja | |||||||||
| 権利情報 | 琉球医学会 | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 93%hepatectomy | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | OK-432 | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | splenectomy | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | reticuloendotherial function | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | The purpose of this study is to evaluate the influence of increased activity of reticuloendothelial function by OK-432 and splenectomy on hepatic regeneration following 93% hepatectomy in rats. Wister-maie rats weighting 240g to 320g were randomly allocated to 4 experimental groups and subjected to the following regimen :(1) A group; 93% hepatectomy alone,(2) B group; 93% hepatectomy+splenectomy, (3) C group; OK-432+93% hepatectomy, (4) D group; OK-432+93% hepatectomy+splenectomy. Survival rates after hepatectomy, initial, 24hour, 48hour, serum endotoxin, S- GOT, S-GPT in each group were determined. The long-term (180 days following hepatectomy) survival rates was 45.5% in A group, 13.6% in B group, 6.4% in Cgroup and 6.3% in D group, respectively and A group survival was statistically significant better compared with other three groups. Serum endotoxin titers prior to hepatectomy were significantly lower (0.926 pg/ml) in OK-432 treated groups than in non-treated groups (3.3pg/ml). 24hours after hepatectomy, A group showed marked increase titers of endotoxin with statistical significance compared with other three groups. S-GOT and S-GPT markedly elevated 24hours after hepatectomy, but returned to the normal values 48hours after hepatectomy. These results might suggest that in 93% experimental hepatectomy in rats, activation of reticuloendotherial function could be harmful in liver regeneration after hepatectomy, and lower survival rate from the long-term survival points, therefore, another unknown mechanism might play an important role in liver damage after hepatectomy. | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 論文 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 琉球医学会 | |||||||||
| 言語 | ja | |||||||||
| 出版者 | ||||||||||
| 出版者 | Ryukyu Medical Association | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1346888X | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0289-1530 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN10369445 | |||||||||
| 収録物名 | ||||||||||
| 収録物名 | 琉球医学会誌 = Ryukyu Medical Journal | |||||||||
| 言語 | ja | |||||||||
| 書誌情報 |
巻 12, 号 4, p. 317-326, 発行日 1992 |
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