@article{oai:u-ryukyu.repo.nii.ac.jp:02015920,
 author = {磯, 淳典 and 平良, 豊 and 垣花, 脩 and 濱田, 哲 and 奥田, 佳朗 and Iso, Atunori and Taira, Yutaka and Kakinohana, Osamu and Hamada, Satosi and Okuda, Yoshiaki},
 issue = {4},
 journal = {琉球医学会誌 = Ryukyu Medical Journal},
 month = {},
 note = {To evaluate the effects of bupivacaine on lidocaine metabolism mediated by chtochrome P-450, we analyzed enzyme kinetics in an in vitro study using rat liver microsomes and pharmacokinetics in an in vivo study using anesthetized dogs. In vitro study,bupivacaine showed mixed type inhibition of hdocaine metabolism with inhibition constants being 1.38mM. Since bupivacaine did not affect cytochrome C reductase activity,this inhibition of lidocaine metabolism may have been caused by the action on cytochrome P-450. In vivo study, there was no difference between pharmacokinetic parameter after lidocaine alone injection and lidocaine mixed with bupivacaine injection., 論文},
 pages = {375--382},
 title = {[原著］リドカイン代謝に及ぼすブピバカインの影響 : in vitro, in vivo での検討},
 volume = {12},
 year = {1992}
}