{"created":"2022-02-22T03:32:13.822655+00:00","id":2015920,"links":{},"metadata":{"_buckets":{"deposit":"d1d9abb6-0497-4d9e-81df-bb861799644a"},"_deposit":{"id":"2015920","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2015920"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02015920","sets":["1642838163960:1642838198944:1642838199408:1642838201426","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[原著］リドカイン代謝に及ぼすブピバカインの影響 : in vitro, in vivo での検討","subitem_1551255648112":"ja"},{"subitem_1551255647225":"Effects of Bupivacaine on in vitro and in vivo Lidocaine metabolism","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"磯, 淳典","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"平良, 豊","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"垣花, 脩","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"濱田, 哲","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"奥田, 佳朗","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"Iso, Atunori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Taira, Yutaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kakinohana, Osamu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hamada, Satosi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okuda, Yoshiaki","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"biotransformation"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"pharmacokinetics"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"enzyme inhibition"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"lidocain"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"bupivacaine"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"To evaluate the effects of bupivacaine on lidocaine metabolism mediated by chtochrome P-450, we analyzed enzyme kinetics in an in vitro study using rat liver microsomes and pharmacokinetics in an in vivo study using anesthetized dogs. In vitro study,bupivacaine showed mixed type inhibition of hdocaine metabolism with inhibition constants being 1.38mM. Since bupivacaine did not affect cytochrome C reductase activity,this inhibition of lidocaine metabolism may have been caused by the action on cytochrome P-450. In vivo study, there was no difference between pharmacokinetic parameter after lidocaine alone injection and lidocaine mixed with bupivacaine injection.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"jpn"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"382","bibliographicPageStart":"375","bibliographicVolumeNumber":"12"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v12p375.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2015920/files/v12p375.pdf"},"version_id":"c1ce1399-33b5-4b9b-86d4-184ea6d00c66"}]},"item_title":"[原著］リドカイン代謝に及ぼすブピバカインの影響 : in vitro, in vivo での検討","item_type_id":"15","owner":"1","path":["1642838201426","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2015920","relation_version_is_last":true,"title":["[原著］リドカイン代謝に及ぼすブピバカインの影響 : in vitro, in vivo での検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:46:58.010138+00:00"}