{"created":"2022-02-22T04:09:46.883620+00:00","id":2015971,"links":{},"metadata":{"_buckets":{"deposit":"d4af1aae-a62a-49df-a3e7-d2950bc93e07"},"_deposit":{"id":"2015971","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2015971"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02015971","sets":["1642838163960:1642838198944:1642838199408:1642838206792","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[総説］Physiological significance of protease in airway secretion and the control of inflammation in airway tract by protease inhibitor","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tamaki, Noboru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kosugi, Tadayoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hanashiro, Kazuhiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamura, Mariko","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"protease"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"antiprotease"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"plasminogen activator"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"tracheobronchial secretion"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"We review the action of protease in airway inflammation from the standpoint of the protease-antiprotease system. The tracheobronchial secretion without inflammation has an abundant protease, plasminogen activator (PA) , which plays an important role in the continuous opening of the tracheobronchial lumina. Immediately after inflammation occurs in the airway tract, the protease activity is increased in the airway secretion, as compared to the protease activity in other organs. On the other hand, increased protease secretion, plays a strong role in the enlargement and exacerbation of the inflammation. In physiological inflammation, the increased protease activity is mediated and inhibited by protease inhibitor which is concomitantly elevated at the inflammatory locus. In inflammation of the airway tract, therefore, the application and supply of protease inhibitor to the airway tract, should cause the inflammation to subside. We consider that the role of protease inhibitor in limiting the inflammation of the airway tract is of clinical importance.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"126","bibliographicPageStart":"121","bibliographicVolumeNumber":"15"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v15p121.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2015971/files/v15p121.pdf"},"version_id":"ba3dac28-f699-46b8-bd1a-6626abf2f682"}]},"item_title":"[総説］Physiological significance of protease in airway secretion and the control of inflammation in airway tract by protease inhibitor","item_type_id":"15","owner":"1","path":["1642838206792","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2015971","relation_version_is_last":true,"title":["[総説］Physiological significance of protease in airway secretion and the control of inflammation in airway tract by protease inhibitor"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:47:54.053993+00:00"}