{"created":"2022-02-22T04:11:02.012594+00:00","id":2016013,"links":{},"metadata":{"_buckets":{"deposit":"9d609dae-bd8e-4b35-9468-78ca1af09c6a"},"_deposit":{"id":"2016013","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2016013"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02016013","sets":["1642838163960:1642838198944:1642838199408:1642838206201","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[原著］Administration of histamine-rat gammaglobulin conjugate suppresses IgE production in rats","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hanashiro, Kazuhiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sunagawa, Masanori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Saitoh, Shigeru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamura, Mariko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kosugi, Tadayoshi","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"histamine-rat gammaglobulin conjugate (HRG)"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"IgE"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"suppression"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"We evaluated the effect of administration of histamine-rat gammaglobulin conjugate (HRG) on the production of IgE in rats. The antigen-specific IgE level in the serum measured by PCA reaction decreased in the HRG-administered group, compared to that in the physiological saline-administered control group on day 15 after sensitization with DNP-Ascaris antigen. However, on day 10, HRG significantly increased the concentration of histamine compared to that in the control group. The IgG_1 level was higher in the HRG-administered group on day 15 and day 20, compared to that in the control group. From these results and the observation that the IgE production in rats increased to the highest level on day 15, we concluded that the decrease in PCA titer induced by the administration of HRG in rats was not dependent on an increase in IgE consumption, but on a decrease in IgE production. The increased histamine and IgG_1 level by the administration of HRG might have directly or indirectly suppressed the IgE production in rats.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"17","bibliographicPageStart":"13","bibliographicVolumeNumber":"15"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v15p13.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2016013/files/v15p13.pdf"},"version_id":"a1b5a4a0-f8e8-4b2f-882c-9ae4afae5931"}]},"item_title":"[原著］Administration of histamine-rat gammaglobulin conjugate suppresses IgE production in rats","item_type_id":"15","owner":"1","path":["1642838206201","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2016013","relation_version_is_last":true,"title":["[原著］Administration of histamine-rat gammaglobulin conjugate suppresses IgE production in rats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:48:39.878562+00:00"}