{"created":"2022-02-22T04:11:12.378379+00:00","id":2016019,"links":{},"metadata":{"_buckets":{"deposit":"a07d1e49-cdb4-4d26-8495-178cf8cba03d"},"_deposit":{"id":"2016019","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2016019"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02016019","sets":["1642838163960:1642838198944:1642838199408:1642838205767","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[総説］本態性高血圧におけるミネラルコルチコイドの関与について","subitem_1551255648112":"ja"},{"subitem_1551255647225":"The role of mineralocorticoids in the patients with essential hypertension","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小宮, 一郎","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"高須, 信行","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"Komiya, Ichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takasu, Nobuyuki","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Based on experiments with excess sodium, it is hypothesized that a high blood pressure is needed for renal excretion of sodium in patients with essential hypertension. The effect of a more moderate increase in dietary sodium intake on blood pressure has not been systematically studied. A possible additional role of aldosterone on blood pressure is not well studied. We used 3222 normal subjects, 741 patients with essential hypertension, 20 patients with aldosterone-producing adenoma and 10 patients with ldiopathic hyperaldosteronism to study a possible role of sodium, renal function and aldosterone on blood pressure elevation. When compared with the controls, serum sodium concentration shifted (about 2 mEq/1) to the right in patients with essential hypertension. The incidence of upper normal serum sodium (147 mEq/1 or more) was significantly higher in hypertensive patients  than in normal controls. Age-related deterioration of renal function did not explain hypertension and abnormal sodium metabolism in hypertensive patients. In hypertensive patients with normal serum sodium (70-75% of total hypertensive patients) and upper normal serum sodium (10-12% of total), aldosterone correlated well with PRA, and PRA correlated well with serum sodium, whereas such correlations were not found in hypertensive patients with upper normal sodium plus elevated aldosterone/PRA ratio (9-12% of total), the finding being similar to those of APA and IHA. Serum sodium distribution pattern was different between normal subjects and patients with essential hypertension, and, as a result, upper normal sodium was frequently found in hypertensive patients. Generally employed renal function did not explain this abnormal sodium metabolism. Nine to 12% of hypertensive patients have upper normal sodium and inappropriate elevation of aldosterone (suppressed PRA and unsuppressed aldosterone). It is suggested that, if excess sodium was taken in those patients, further elevation of blood pressure is induced because of lack of compensatory mechanism for further renal excretion of sodium.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"jpn"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"12","bibliographicPageStart":"7","bibliographicVolumeNumber":"15"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v15_1p7.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2016019/files/v15_1p7.pdf"},"version_id":"647e6c33-1e30-47db-b49e-acd496bbc84c"}]},"item_title":"[総説］本態性高血圧におけるミネラルコルチコイドの関与について","item_type_id":"15","owner":"1","path":["1642838205767","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2016019","relation_version_is_last":true,"title":["[総説］本態性高血圧におけるミネラルコルチコイドの関与について"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:48:46.274523+00:00"}