{"created":"2022-02-22T04:11:38.948875+00:00","id":2016034,"links":{},"metadata":{"_buckets":{"deposit":"e223c1fd-e452-4295-bfee-e86a848e941a"},"_deposit":{"id":"2016034","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2016034"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02016034","sets":["1642838163960:1642838198944:1642838199408:1642838211097","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[原著］Radio frequency thermal coagulation therapy for lung tumors : An experimental study","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Asai, Toshiharu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanigawa, Noboru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanabe, MasaoJ","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Lung tumor"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Radiofrequency"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Coagulation therapy"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"We developed a thermal coagulation therapy using radio frequency dielectric warming as a local therapy for lung tumors and conducted a basic study of the procedure involved. A fine needie was percutaneously inserted into the tumor and radio frequency waves emanating from the tip of the needle were converted to thermal energy, which serves to denature and necrotize the tumor cells. In order to evaluate the cytocidal effect of this method, cells of tumor tissue subjected to thermal coagulation were cultured and their morphology was evaluated histologically. Twenty-three male Japanese white rabbits weighing 2 - 3 kg were used. A cell suspension of rabbit VX-2 tumor (10^6/0.3 ml/rabbit) was injected through the ear veins of the rabbits and 70 tumors with a diameter of 2 - 3 mm exposing on the pleural surface of the lung were collected 2 weeks later and used as implanted lung tumors. For thermal coagulation, the current was supplied for lO seconds (N = 19), 20 seconds (N = 17) and 30 seconds (N = 26); while O second (N = 8) served as a control. Among the 70 tumors, 30 were used for cell culture and 40 for tissue specimens. In the culture study, cells from a single tumor were cultured and a growth curve was plotted. The number of viable cells grown following current supply fell significantly in comparison with the group with no current supply (Student's t-test, p < O.C1). There was no significant difference in viable cell count, however, among groups receiving current supply of various durations (10 seconds, 20 seconds, and 30 seconds). As for the effect on growth capacity, there was no significant difference between viable cell counts immediately after current supply and those 14 days later in groups receiving current supply for 10 seconds and 20 seconds. In the group receiving current supply for 30 seconds, viable cell count decreased significantly both immediately after current supply and 14 days later (p < 0.05). The temperature in the marginal part of the tumors was 64.8℃ on average at the time of dielectric warming. In tissue specimens, destruction of pulmonary alveolar structure accompanied by very slight emphysematous change in the pulmonary tissue surrounding the tumors was observed in 5 of40 specimens (13%). From these results, it was concluded that this could serve as a new therapeutic procedure for lung cancer tumors.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"209","bibliographicPageStart":"203","bibliographicVolumeNumber":"17"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v17p203.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2016034/files/v17p203.pdf"},"version_id":"63145ade-1bb5-45ec-856e-d73a98880b73"}]},"item_title":"[原著］Radio frequency thermal coagulation therapy for lung tumors : An experimental study","item_type_id":"15","owner":"1","path":["1642838211097","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2016034","relation_version_is_last":true,"title":["[原著］Radio frequency thermal coagulation therapy for lung tumors : An experimental study"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:49:02.761813+00:00"}