@article{oai:u-ryukyu.repo.nii.ac.jp:02016039,
 author = {小杉, 忠誠 and 砂川, 昌範 and 花城, 和彦 and 金城, 紀代彦 and 中村, 真理子 and Kosugi, Tadayoshi and Sunagawa, Masanori and Hanashiro, Kazuhiko and Kinjoh, Kiyohiko and Nakamura, Mariko},
 issue = {1-2},
 journal = {琉球医学会誌 = Ryukyu Medical Journal},
 month = {},
 note = {Extracellular matrix of the ovary during ovulation is degraded and remodelled. After ovulation, angiogenesis and repair occur in the ovary. The dynamic change of extracellular matrix during ovulation is based on the role of proteolytic enzymes. Besides the fibnnolytic enzymes, the enzymes of collagenolytic system play important role in ovulation. In this article, we report that interstitial collagenase, type IV collagenase, collagenase inhibitor, tissue inhibitor of metalloproteinase 1 (TIMP-1) which belong to collagenolytic system play important role in the rupture of follicle, the migration of oocyte and the expulsion of oocyte from the ovary. During gonadotropin-induced ovulation, at 3 hr to 6 hr after hCG administration the interstitial collagenase mRNA increased, but at 9 hr after hCG administration TIMP-I mRNA and collagenase type IV mRNA increased in the granulosa cell, thecal compartment and stroma compartment. Both the interstitial collagenase and type IV collagenase were secreted in the latent form (procollagenase). This latent form, procollagenase was activated by fibrinolytic enzyme, plasmin and converted to active collagenase. It was clarified that the cross talk of fibrinolytic enzymes and collagenolytic enzyme has been observed in the process of ovulation., 論文},
 pages = {11--14},
 title = {[総説］排卵への蛋白分解酵素の役割 : (2)コラーゲン分解系の役割},
 volume = {18},
 year = {1998}
}