{"created":"2022-02-22T04:12:56.480398+00:00","id":2016073,"links":{},"metadata":{"_buckets":{"deposit":"d789ff7e-022c-4188-a9bc-ccaafa8002c1"},"_deposit":{"id":"2016073","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2016073"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02016073","sets":["1642838163960:1642838198944:1642838199408:1642838213103","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[原著］Protective effects of lidocaine in hepatic ischemia : reperfusion injury in-vivo and ex-vivo","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tomori, Hirofumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shiraishi, Masayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Muto, Yoshihiro","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"lidocaine"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"liver"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"ischemia/reperfusion injury"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"in-vivo"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"ex-vivo"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"We investigated the effect of lidocaine on hepatic ischemia/reperfusion (I/R) injury in the rat both in vivo (ExperimentA, groups 1 to 3) and ex vivo (Experiment B, groups 4 to 7). In Experiment A, hepatic ischemia were performed for 60 min at room temperature. In groups 1 and 2, physiological saline (group 1, n=5) or 10 mg/kg of lidocaine (group 2, n=5) was injected through the peripheral vein, before the hepatic ischemia. In group 3 (n=5), 10 mg/kg of lidocaine was injected twice at reperfusion and before hepatic ischemia. The hepatic tissue blood flowingroup 1 was lower than in group 2 or 3 at 5 min to 90 min after reperfusion. Serum transaminase level was significantly lower in group 3 compared to that in group 1 at 2 hours after reperfusion. In Experiment B, livers were removed from the rat and preserved in saline at room temperature for 60 min, followed by 120 min of reperfusion with oxygenated perfusate at 37℃. The livers were perfused with Krebs-Henseleit solution (group 4, n=5). The perfusate was supplemented with lidocaine in group 5 (n=5), 3.5×10^6 of neutrophil in group 6 (n=5), and both lidocaine and neutrophils in group 7 (n=5). The levels of GOT, GPT and LDH were all significantly lower in group 7 than in group 6. These data thus suggest that lidocaine plays a protective role in hepatic I/R injury by stabilizing both the hepatocytes and the neutrophil membrane.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"16","bibliographicPageStart":"11","bibliographicVolumeNumber":"19"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v19p11.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2016073/files/v19p11.pdf"},"version_id":"b1455791-1d62-4631-ba5b-8fe1aab2ae83"}]},"item_title":"[原著］Protective effects of lidocaine in hepatic ischemia : reperfusion injury in-vivo and ex-vivo","item_type_id":"15","owner":"1","path":["1642838213103","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2016073","relation_version_is_last":true,"title":["[原著］Protective effects of lidocaine in hepatic ischemia : reperfusion injury in-vivo and ex-vivo"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:49:50.566157+00:00"}