{"created":"2022-02-22T04:13:16.368478+00:00","id":2016083,"links":{},"metadata":{"_buckets":{"deposit":"64c1ebed-bf33-44a3-9c73-ba73fb109553"},"_deposit":{"id":"2016083","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2016083"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02016083","sets":["1642838163960:1642838198944:1642838199408:1642838211991","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[原著］In-situ perfusion of the liver as a stable model of cold ischemia in orthotopic liver transplantation","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shiraishi, Masayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nozato, Eiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okuhama, Yukihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tomori, Hirofumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Higa, Takao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Taira, Kaoru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Muto, Yoshihiro","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"ischemia reperfusion injury"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"liver"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"in-situ per fusion"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Various models of hepatic ischemia/reperfusion (I/R) injury were tested, using both rats (groups 1, 2 and 3, each n=10) and pigs (groups4 and5, each n=5). To create cold ischemia for 1 hr, an orthotopic liver transplantation (OLT) was performed in groups 1 and 4 using the cuff technique to reconstruct the portal vein and infra-hepatic vein in group 1, and using the veno-venous bypass during a non-hepatic phase in group 4. In groups 3 and 5, in-situ perfusion of the liver was performed without taking out the liver under a portosystemic shunt, which was achieved by a splenic transposition (created 4 weeks prior to the surgery) in group 3, and by a pump controlled veno-venous bypass in group 5. In group 2, a simple clamp of the portal triads was applied, without flushing out the blood from the liver. The survival rate at 1 week after surgery was 90% (9/10), 70% (7/10), 100% (10/10), 60% (3/5), 100% (5/5) in groups 1 to 5, respectively. Regarding the macroscopic findings of the liver 1 week after ischemia, lobar necrosis (1 case) and patchy necrosis (3 case) were characteristically found in group 1, but not in either groups 2 or 3. The serum hepatic enzyme levels showed a large deviation from case to case in groups 1, 2, and 4, in response to the same amount of cold ischemia. However, these values were relatively uniform in groups 3 and 5, in which in-situ per fusion was performed. In conclusion, the above described in-situ perfusion model of the liver is thus considered to provide a stable in-vivo model for studying hepatic I/R injury, in both rats and pigs.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"77","bibliographicPageStart":"73","bibliographicVolumeNumber":"18"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v18p73.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2016083/files/v18p73.pdf"},"version_id":"16f850ad-de36-4f10-ab23-0a38cca2db85"}]},"item_title":"[原著］In-situ perfusion of the liver as a stable model of cold ischemia in orthotopic liver transplantation","item_type_id":"15","owner":"1","path":["1642838211991","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2016083","relation_version_is_last":true,"title":["[原著］In-situ perfusion of the liver as a stable model of cold ischemia in orthotopic liver transplantation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:50:04.962952+00:00"}